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. 2020 Jul 27;153(4):044115. doi: 10.1063/5.0012494

FIG. 1.

FIG. 1.

A thermodynamic cycle that uses the low-level (L) method as a reference potential to indirectly compute the free energy difference between states A and B at the high (H) level. In this work, we focus on a single vertical leg and discuss the computation of ΔGLH.