1. Template of 'Summary of findings' table (direct comparison).

DPP4i, GLP‐1RA, and SGLT2i for CVD
Patient or population: Adults with clinically diagnosed CVD Setting: Hospital Intervention: DPP4‐inhibitors or GLP‐1 receptor agonists or SGLT‐2 inhibitors (monotherapy or combination therapy) Comparison: A combined comparison group of controls such as placebo, lifestyle/behavioural intervention, and another glucose‐lowering pharmacological intervention
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with control	Risk with treatment
Cardiovascular mortality	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
Myocardial infarctions (fatal or non‐fatal)	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
Stroke (fatal or non‐fatal)	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
				[]
All‐cause mortality	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
Hospitalisation for heart failure	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
Non‐cardiac safety outcomes	[value] percent	[value] percent	RR [value] ([value] to [value])	[value]	⊕○○○ very low ⊕⊕○○ low ⊕⊕⊕○ moderate ⊕⊕⊕⊕ high
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio.
GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect