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. 2016 Mar 22;2016(3):CD002124. doi: 10.1002/14651858.CD002124.pub2

Akhavan Amjadi 2009.

Methods Parallel‐group RCT
47 women analysed, unclear how many randomised
Participants Included: single women with moderate to severe primary dysmenorrhoea. Regular periods cycles and with medium to severe pain
Excluded: women with any known disease, signs of vaginal infection, history of pelvic inflammatory disease, myoma or tumour, drug or plant allergies, stressful incidence (parental divorce, or relative deaths) in the past 6 months or during the treatment. Incomplete questionnaire or missed a dose
Age: 18 to 30 years (mean 20.96)
Source: student population
Location: Iran, Gilan University
Interventions Group 1: cinnamon powder (26 analysed)
Group 2: placebo (21 analysed)
Dosing regimen: 420 mg
Total daily dose: 5 capsules per day up to 3 days after pain started for 2 consecutive menstrual cycles
Outcomes
  • Pain on a 0 to 3 scale.

Notes The review author Vahid Seyfoddin (VS) translated this article from Persian to English
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: the method was unclear (study authors reported a formula).
Allocation concealment (selection bias) Unclear risk Comment: the method of allocation concealment was not reported.
Blinding (performance bias and detection bias) 
 All outcomes Low risk Comment: triple blinded (patients, clinicians, and statisticians were all blinded). The placebo and cinnamon capsule were completely identical and were manufactured by the same company. They were packed in an identical package and were distinguishable by a code on the packets.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: the study authors did not state the initial number of participants randomised. The final number analysed was 47 (26 in cinnamon treated group and 21 in placebo).
Selective reporting (reporting bias) Unclear risk Comment: adverse effects were not reported.
Other bias Low risk Comment: we did not identify any other likely sources of bias.