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. 2016 Mar 22;2016(3):CD002124. doi: 10.1002/14651858.CD002124.pub2

Nazarpour 2007.

Methods RCT, parallel‐group
Participants Included: students with moderate to severe primary dysmenorrhoea
Excluded: underlying disease (which leads to dysmenorrhoea Secondary cause, such as endometriosis, myoma, ovarian tumours). And contraindications to the use of drugs.
Age: mean 20.7 years
Source: student population
Location: Iran
Interventions Group 1: fennel (N = 36)
Group 2: mefenamic acid (N = 36)
Group 3: placebo (N = 32)
Dosing regimen: 2 cycles
Total daily dose: fennel 20 to 30 drops every 4 to 8 hours (according to need)
Mefenamic acid: 250 mg every 6 hours (100 mg/day)
Outcomes
  • Pain;

  • dysmenorrhoea symptoms.

Notes Translated from Persian
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: the study authors did not report the method of sequence generation.
Allocation concealment (selection bias) Unclear risk Comment: the study authors did not report the method of allocation concealment.
Blinding (performance bias and detection bias) 
 All outcomes Low risk Comment: both the clinician and participants were blinded.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: the study authors included 104/120 participants (86%) in the analyses.
Selective reporting (reporting bias) Unclear risk Comment: does not systematically report adverse events.
Other bias Low risk Comment: we did not identify any other potential sources of bias.