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. 2016 Mar 22;2016(3):CD002124. doi: 10.1002/14651858.CD002124.pub2

Davis 1988.

Methods Design: repeated measures parallel trial
 Method of allocation and concealment: random but method unclear
 Blinding: double blind
 Number of subjects at outset: unclear (see notes)
 Withdrawals: 2 (reasons unclear)
Participants Inclusion: primary dysmenorrhoea with moderate to severe cramping, regular menstruation
 Exclusion: over the counter medication, vitamins or minerals, use of OCP or IUD, secondary dysmenorrhoea, health or reproductive problems
 Age: 18 to 35 years
 Location: college campus in Texas, USA
Interventions Group 1: vitamin B6 200 mg daily (N = 10)
 Group 2: magnesium 500 mg daily (N = 13)
 Group 3: vitamin B6 200 mg plus magnesium 500 mg daily (N = 12 or 11)
 Group 4: pressed lactose placebo (N = 11)
 Duration: 5 consecutive cycles (1 pretreatment and 4 with treatment)
Outcomes
  • Menstrual pain scores;

  • plasma mineral levels;

  • symptom of stress inventory;

  • erythrocyte magnesium levels;

  • additional medication.

Notes Dissertation
 On page 85 the study author states "only women with menstrual cramping {n=46} included", but on page 38 they state 47 women
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