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. 2012 Aug 15;2012(8):CD007566. doi: 10.1002/14651858.CD007566.pub2

Comparison 1. Health‐related quality of life.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Overall quality of life change score 15   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.1.1 Up to 12 weeks' follow‐up 11 826 Std. Mean Difference (IV, Random, 95% CI) 0.48 [0.16, 0.81]
1.1.2 More than 12 weeks' to less than 6 months' follow‐up 3 181 Std. Mean Difference (IV, Random, 95% CI) 0.14 [‐0.38, 0.66]
1.1.3 6 months' follow‐up 2 115 Std. Mean Difference (IV, Random, 95% CI) 0.46 [0.09, 0.84]
1.2 Overall quality of life values 20   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.2.1 Up to 12 weeks' follow‐up 16 760 Std. Mean Difference (IV, Random, 95% CI) 0.49 [0.24, 0.74]
1.2.2 More than 12 weeks' to less than 6 months' follow‐up 5 353 Std. Mean Difference (IV, Random, 95% CI) 0.11 [‐0.10, 0.32]
1.2.3 6 months' follow‐up 2 115 Std. Mean Difference (IV, Random, 95% CI) 0.25 [‐0.12, 0.62]
1.3 FACT An change 2   Mean Difference (IV, Random, 95% CI) Subtotals only
1.3.1 Up to 12 weeks' follow‐up 2 183 Mean Difference (IV, Random, 95% CI) 7.10 [1.50, 12.71]
1.4 FACT‐An follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
1.4.1 Up to 12 weeks' follow‐up 2 174 Mean Difference (IV, Random, 95% CI) 4.25 [‐3.28, 11.78]
1.5 FACT‐B change 3   Mean Difference (IV, Random, 95% CI) Subtotals only
1.5.1 Up to 12 weeks' follow‐up 2 96 Mean Difference (IV, Random, 95% CI) 9.29 [‐3.73, 22.30]
1.5.2 More than 12 weeks' to less than 6 months' follow‐up 1 52 Mean Difference (IV, Random, 95% CI) 8.80 [2.34, 15.26]
1.5.3 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) 8.20 [‐0.29, 16.69]
1.6 FACT‐B follow‐up values 5   Mean Difference (IV, Random, 95% CI) Subtotals only
1.6.1 Up to 12 weeks' follow‐up 4 188 Mean Difference (IV, Random, 95% CI) 9.82 [‐0.76, 20.40]
1.6.2 More than 12 weeks' to less than 6 months' follow‐up 2 112 Mean Difference (IV, Random, 95% CI) 4.83 [‐1.71, 11.36]
1.6.3 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) 1.90 [‐11.33, 15.13]
1.7 FACT‐C change 1 93 Mean Difference (IV, Random, 95% CI) ‐1.30 [‐7.19, 4.59]
1.7.1 More than 12 weeks' to less than 6 months' follow‐up 1 93 Mean Difference (IV, Random, 95% CI) ‐1.30 [‐7.19, 4.59]
1.8 FACT‐C follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
1.8.1 Up to 12 weeks' follow‐up 1 17 Mean Difference (IV, Random, 95% CI) 14.00 [2.59, 25.41]
1.8.2 More than 12 weeks' to less than 6 months' follow‐up 1 93 Mean Difference (IV, Random, 95% CI) ‐2.40 [‐10.19, 5.39]
1.9 FACT‐G change 6   Mean Difference (IV, Random, 95% CI) Subtotals only
1.9.1 Up to 12 weeks' follow‐up 3 198 Mean Difference (IV, Random, 95% CI) 4.94 [‐0.08, 9.95]
1.9.2 More than 12 weeks' to less than 6 months' follow‐up 2 145 Mean Difference (IV, Random, 95% CI) 2.10 [‐3.98, 8.17]
1.9.3 6 months' follow‐up 2 110 Mean Difference (IV, Random, 95% CI) 3.93 [0.45, 7.40]
1.10 FACT‐G follow‐up values 9   Mean Difference (IV, Random, 95% CI) Subtotals only
1.10.1 Up to 12 weeks' follow‐up 6 318 Mean Difference (IV, Random, 95% CI) 5.90 [‐0.36, 12.16]
1.10.2 More than 12 weeks' to less than 6 months' follow‐up 3 207 Mean Difference (IV, Random, 95% CI) 1.79 [‐1.93, 5.50]
1.10.3 6 months' follow‐up 2 110 Mean Difference (IV, Random, 95% CI) 3.73 [‐2.08, 9.53]
1.11 FACIT change 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.11.1 Up to 12 weeks' follow‐up 2   Mean Difference (IV, Random, 95% CI) Totals not selected
1.12 FACIT follow‐up values 1 21 Mean Difference (IV, Random, 95% CI) ‐2.60 [‐21.19, 15.99]
1.12.1 Up to 12 weeks' follow‐up 1 21 Mean Difference (IV, Random, 95% CI) ‐2.60 [‐21.19, 15.99]
1.13 QLQ‐C30 change 3   Mean Difference (IV, Random, 95% CI) Subtotals only
1.13.1 Up to 12 weeks' follow‐up 2 73 Mean Difference (IV, Random, 95% CI) 15.66 [‐7.78, 39.09]
1.13.2 More than 12 weeks' less than 6 months' follow‐up 1 101 Mean Difference (IV, Random, 95% CI) ‐1.60 [‐8.15, 4.95]
1.14 QLQ‐C30 follow‐up values 4   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.14.1 Up to 12 weeks' follow‐up 3 109 Mean Difference (IV, Fixed, 95% CI) 13.80 [7.17, 20.43]
1.14.2 More than 12 weeks' less than 6 months' follow‐up 1 101 Mean Difference (IV, Fixed, 95% CI) ‐0.50 [‐7.13, 6.13]
1.15 CARES follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.15.1 6 months' follow‐up 1 79 Mean Difference (IV, Random, 95% CI) ‐3.20 [‐7.19, 0.79]
1.16 CARES change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.16.1 6 months' follow‐up 1 79 Mean Difference (IV, Random, 95% CI) ‐1.70 [‐3.58, 0.18]
1.17 Chae and Cho change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.17.1 Up to 12 weeks' follow‐up 1 55 Mean Difference (IV, Random, 95% CI) 1.00 [0.39, 1.61]
1.18 Chae and Cho follow‐up values 1 55 Mean Difference (IV, Random, 95% CI) 0.70 [0.01, 1.39]
1.18.1 Up to 12 weeks' follow‐up 1 55 Mean Difference (IV, Random, 95% CI) 0.70 [0.01, 1.39]
1.19 QoL Index follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.19.1 Up to 12 weeks' follow‐up 1 21 Mean Difference (IV, Random, 95% CI) 3.30 [‐5.35, 11.95]