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. 2012 Aug 15;2012(8):CD007566. doi: 10.1002/14651858.CD007566.pub2

Comparison 5. Cognitive functioning.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Overall cognitive functioning change 5   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.1.1 Up to 12 weeks' follow‐up 5 332 Std. Mean Difference (IV, Random, 95% CI) ‐0.06 [‐0.38, 0.26]
5.1.2 6 months' follow‐up 1 36 Std. Mean Difference (IV, Random, 95% CI) ‐0.23 [‐0.89, 0.43]
5.2 Overall cognitive functioning follow‐up values 10   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.2.1 Up to 12 weeks' follow‐up 9 439 Std. Mean Difference (IV, Random, 95% CI) 0.29 [‐0.57, 1.16]
5.2.2 More than 12 weeks' less than 6 months' follow‐up 3 186 Std. Mean Difference (IV, Random, 95% CI) ‐0.26 [‐0.55, 0.03]
5.3 QLQ‐C30 cognitive function change 3   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.3.1 Up to 12 weeks' follow‐up 3 127 Mean Difference (IV, Fixed, 95% CI) 3.31 [‐2.92, 9.53]
5.4 QLQ‐C30 cognitive function follow‐up values 5   Mean Difference (IV, Random, 95% CI) Subtotals only
5.4.1 Up to 12 weeks' follow‐up 4 256 Mean Difference (IV, Random, 95% CI) 4.47 [‐0.35, 9.28]
5.4.2 More than 12 weeks' less than 6 months' follow‐up 2 150 Mean Difference (IV, Random, 95% CI) 6.15 [‐0.30, 12.59]
5.5 FACT Cog change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
5.5.1 Up to 12 weeks' follow‐up 1 38 Mean Difference (IV, Random, 95% CI) ‐8.90 [‐22.95, 5.15]
5.5.2 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) ‐4.72 [‐18.12, 8.68]
5.6 FACT‐Cog follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
5.6.1 12 weeks' follow‐up 1 37 Mean Difference (IV, Random, 95% CI) ‐11.00 [‐27.52, 5.52]
5.6.2 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) ‐2.80 [‐23.50, 17.90]
5.7 Linear Analog Self‐Assessment Scale ‐ confusion follow‐up values 1 21 Mean Difference (IV, Random, 95% CI) ‐4.90 [‐17.70, 7.90]
5.7.1 Up to 12 weeks' follow‐up 1 21 Mean Difference (IV, Random, 95% CI) ‐4.90 [‐17.70, 7.90]
5.8 POMS confusion subscale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
5.8.1 Up to 12 weeks' follow‐up 1 167 Mean Difference (IV, Random, 95% CI) 1.15 [‐0.71, 3.01]
5.9 Profile of Mood State confusion subscale follow‐up values 4 233 Mean Difference (IV, Random, 95% CI) ‐1.62 [‐2.53, ‐0.71]
5.9.1 Up to 12 weeks' follow‐up 4 233 Mean Difference (IV, Random, 95% CI) ‐1.62 [‐2.53, ‐0.71]
5.10 Symptoms of Stress Inventory ‐ cognitive disorganization subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
5.10.1 Up to 12 weeks' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) ‐1.67 [‐3.66, 0.32]