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. 2012 Aug 15;2012(8):CD007566. doi: 10.1002/14651858.CD007566.pub2

Comparison 8. Fatigue.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
8.1 Overall fatigue change 14   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
8.1.1 Up to 12 weeks' follow‐up 10 745 Std. Mean Difference (IV, Random, 95% CI) ‐0.82 [‐1.50, ‐0.14]
8.1.2 More than 12 weeks' less than 6 months' follow‐up 3 246 Std. Mean Difference (IV, Random, 95% CI) ‐0.42 [‐0.83, ‐0.02]
8.1.3 6 months' follow‐up 3 514 Std. Mean Difference (IV, Random, 95% CI) ‐0.06 [‐0.31, 0.19]
8.1.4 More than 6 months' follow‐up 1 82 Std. Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.82, 0.06]
8.2 Overall fatigue follow‐up values 22   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
8.2.1 Up to 12 weeks' follow‐up 18 994 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.46, ‐0.14]
8.2.2 More than 12 weeks' less than 6 months' follow‐up 5 436 Std. Mean Difference (IV, Random, 95% CI) ‐0.03 [‐0.31, 0.25]
8.2.3 6 months' follow‐up 2 110 Std. Mean Difference (IV, Random, 95% CI) ‐0.10 [‐0.48, 0.27]
8.3 FACT fatigue subscale change 6   Mean Difference (IV, Random, 95% CI) Subtotals only
8.3.1 Up to 12 weeks' follow‐up 4 296 Mean Difference (IV, Random, 95% CI) 4.33 [2.43, 6.22]
8.3.2 More than 12 weeks' less than 6 months' follow‐up 2 145 Mean Difference (IV, Random, 95% CI) ‐3.97 [‐10.53, 2.60]
8.3.3 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) 1.28 [‐4.11, 6.67]
8.4 FACT fatigue subscale follow‐up values 11   Mean Difference (IV, Random, 95% CI) Subtotals only
8.4.1 Up to 12 weeks' follow‐up 9 550 Mean Difference (IV, Random, 95% CI) 2.00 [0.00, 3.99]
8.4.2 More than 12 weeks' up to 6 months' follow‐up 3 250 Mean Difference (IV, Random, 95% CI) 0.21 [‐2.04, 2.45]
8.4.3 6 months' follow‐up 1 36 Mean Difference (IV, Random, 95% CI) 0.30 [‐7.22, 7.82]
8.5 QLQ‐C30 fatigue subscale change 4 259 Mean Difference (IV, Random, 95% CI) ‐15.38 [‐39.15, 8.38]
8.5.1 Up to 12 weeks' follow‐up 3 158 Mean Difference (IV, Random, 95% CI) ‐22.45 [‐50.66, 5.77]
8.5.2 More than 12 weeks' less than 6 months' follow‐up 1 101 Mean Difference (IV, Random, 95% CI) 11.20 [2.36, 20.04]
8.6 QLQ‐C30 fatigue subscale follow‐up values 5   Mean Difference (IV, Random, 95% CI) Subtotals only
8.6.1 Up to 12 weeks' follow‐up 4 256 Mean Difference (IV, Random, 95% CI) ‐7.50 [‐12.92, ‐2.07]
8.6.2 More than 12 weeks' less than 6 months' follow‐up 2 206 Mean Difference (IV, Random, 95% CI) 3.03 [‐6.67, 12.73]
8.7 Multidimensional Fatigue Inventory follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.7.1 Up to 12 weeks' follow‐up 1 87 Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.58, 0.16]
8.8 MOS SF‐36 vitality subscale change 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.8.1 Up to 12 weeks' follow‐up 1 58 Mean Difference (IV, Random, 95% CI) 2.90 [‐6.33, 12.13]
8.8.2 6 months' follow‐up 1 74 Mean Difference (IV, Random, 95% CI) 0.40 [‐2.72, 3.52]
8.9 MOS SF‐36 vitality subscale follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.9.1 Up to 12 weeks' follow‐up 1 58 Mean Difference (IV, Random, 95% CI) 8.09 [‐1.39, 17.57]
8.9.2 6 months' follow‐up 1 74 Mean Difference (IV, Random, 95% CI) 1.30 [‐3.03, 5.63]
8.10 Piper Revised Fatigue Scale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.10.1 Up to 12 weeks' follow‐up 1 66 Mean Difference (IV, Random, 95% CI) ‐1.30 [‐2.17, ‐0.43]
8.10.2 More than 12 weeks' less than 6 months' follow‐up 1 59 Mean Difference (IV, Random, 95% CI) ‐0.78 [‐1.83, 0.27]
8.11 Schwartz Cancer Fatigue scale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.11.1 Up to 12 weeks' follow‐up 1 58 Mean Difference (IV, Random, 95% CI) ‐2.20 [‐4.32, ‐0.08]
8.12 Linear Analog Self‐Assessment energy scale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.12.1 Up to 12 weeks' follow‐up 1 21 Mean Difference (IV, Random, 95% CI) ‐19.00 [‐31.89, ‐6.11]
8.13 Linear Analog Self‐Assessment scale change 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.13.1 Up to 12 weeks' follow‐up 1 82 Mean Difference (IV, Random, 95% CI) ‐13.14 [‐23.32, ‐2.96]
8.13.2 6 months' follow‐up 1 404 Mean Difference (IV, Random, 95% CI) ‐2.44 [‐13.06, 8.18]
8.13.3 More than 6 months' follow‐up 1 82 Mean Difference (IV, Random, 95% CI) ‐9.47 [‐20.13, 1.19]
8.14 Linear Analog Self‐Assessment scale follow‐up values 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.14.1 Up to 12 weeks' follow‐up 2 103 Mean Difference (IV, Random, 95% CI) ‐15.40 [‐25.08, ‐5.73]
8.15 Schwartz Cancer Fatigue scale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.15.1 Up to 12 weeks' follow‐up 1 58 Mean Difference (IV, Random, 95% CI) ‐4.00 [‐6.03, ‐1.97]
8.16 POMS fatigue subscale change 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.16.1 Up to 12 weeks' follow‐up 2 275 Mean Difference (IV, Random, 95% CI) ‐0.17 [‐2.25, 1.92]
8.17 POMS ‐ fatigue subscale follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.17.1 Up to 12 weeks' follow‐up 1 24 Mean Difference (IV, Random, 95% CI) ‐1.84 [‐6.96, 3.28]
8.18 POMS vigor subscale change 3   Mean Difference (IV, Random, 95% CI) Subtotals only
8.18.1 Up to 12 weeks' follow‐up 2 275 Mean Difference (IV, Random, 95% CI) 2.37 [‐1.70, 6.44]
8.18.2 6 months' follow‐up 1 82 Mean Difference (IV, Random, 95% CI) 2.23 [‐0.48, 4.94]
8.18.3 More than 6 months' follow‐up 1 82 Mean Difference (IV, Random, 95% CI) 0.84 [‐1.89, 3.57]
8.19 POMS vigor subscale follow‐up values 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
8.19.1 Up to 12 weeks' follow‐up 1 82 Mean Difference (IV, Fixed, 95% CI) 4.77 [2.36, 7.18]
8.20 POMS short form vigor follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.20.1 Up to 12 weeks' follow‐up 1 86 Mean Difference (IV, Random, 95% CI) 0.27 [‐0.07, 0.61]
8.20.2 More than 12 weeks' less than 6 months' follow‐up 1 85 Mean Difference (IV, Random, 95% CI) 0.39 [0.05, 0.73]
8.21 Brief Fatigue Inventory follow‐up values 1   Mean Difference (IV, Random, 95% CI) Subtotals only
8.21.1 Up to 12 weeks' follow‐up 1 30 Mean Difference (IV, Random, 95% CI) 0.00 [‐1.08, 1.08]