Comparison 9. General health perspective.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
9.1 Overall general health change	4		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
9.1.1 Up to 12 weeks' follow‐up	2	96	Std. Mean Difference (IV, Random, 95% CI)	0.11 [‐0.29, 0.51]
9.1.2 6 months' follow‐up	3	189	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.38, 0.44]
9.2 Overall general health follow‐up values	6		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
9.2.1 Up to 12 weeks' follow‐up	4	249	Std. Mean Difference (IV, Random, 95% CI)	0.14 [‐0.20, 0.49]
9.2.2 More than 12 weeks' less than 6 months' follow‐up	1	105	Std. Mean Difference (IV, Random, 95% CI)	0.19 [‐0.19, 0.58]
9.2.3 6 months' follow‐up	3	189	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.30, 0.36]
9.3 QLQ‐C30 subscale follow‐up values	2	288	Mean Difference (IV, Random, 95% CI)	4.03 [0.14, 7.92]
9.3.1 Up to 12 weeks' follow‐up	2	183	Mean Difference (IV, Random, 95% CI)	4.25 [‐1.09, 9.60]
9.3.2 More than 12 weeks' less than 6 months' follow‐up	1	105	Mean Difference (IV, Random, 95% CI)	3.30 [‐3.25, 9.85]
9.4 CARES subscale change	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.4.1 6 months' follow‐up	1	79	Mean Difference (IV, Random, 95% CI)	‐1.30 [‐3.23, 0.63]
9.5 CARES subscale follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.5.1 6 months' follow‐up	1	79	Mean Difference (IV, Random, 95% CI)	‐0.60 [‐3.09, 1.89]
9.6 MOS general health subscale change	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.6.1 Up to 12 weeks' follow‐up	1	58	Mean Difference (IV, Random, 95% CI)	3.36 [‐5.43, 12.15]
9.6.2 6 months' follow‐up	1	74	Mean Difference (IV, Random, 95% CI)	3.00 [‐0.98, 6.98]
9.7 MOS general health subscale follow‐up values	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.7.1 Up to 12 weeks' follow‐up	1	58	Mean Difference (IV, Random, 95% CI)	4.37 [‐4.43, 13.17]
9.7.2 6 months' follow‐up	1	74	Mean Difference (IV, Random, 95% CI)	5.00 [‐1.92, 11.92]
9.8 Single question change	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.8.1 Up to 12 weeks' follow‐up	1	38	Mean Difference (IV, Random, 95% CI)	‐0.02 [‐0.44, 0.40]
9.8.2 6 months' follow‐up	1	36	Mean Difference (IV, Random, 95% CI)	0.04 [‐0.35, 0.43]
9.9 Single question follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.9.1 Up to 12 weeks' follow‐up	1	38	Mean Difference (IV, Random, 95% CI)	‐0.30 [‐0.76, 0.16]
9.9.2 6 months' follow‐up	1	36	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐0.79, 0.39]