Comparison 12. Role function.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
12.1 Overall role function change	9		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
12.1.1 Up to 12 weeks' follow‐up	6	479	Std. Mean Difference (IV, Random, 95% CI)	0.15 [‐0.16, 0.46]
12.1.2 More than 12 weeks' less than 6 months' follow‐up	1	52	Std. Mean Difference (IV, Random, 95% CI)	0.18 [‐0.37, 0.73]
12.1.3 6 months' follow‐up	3	189	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.22, 0.35]
12.2 Overall role function follow‐up values	16		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
12.2.1 Up to 12 weeks' follow‐up	12	719	Std. Mean Difference (IV, Random, 95% CI)	0.27 [0.04, 0.50]
12.2.2 More than 12 weeks' less than 6 months' follow‐up	4	263	Std. Mean Difference (IV, Random, 95% CI)	0.18 [‐0.06, 0.42]
12.2.3 6 months' follow‐up	3	189	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.13, 0.44]
12.3 FACT functional well‐being subscale change	6		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.3.1 Up to 12 weeks' follow‐up	4	406	Mean Difference (IV, Random, 95% CI)	0.70 [‐0.96, 2.36]
12.3.2 More than 12 weeks' less than 6 months' follow‐up	1	52	Mean Difference (IV, Random, 95% CI)	0.50 [‐1.00, 2.00]
12.3.3 6 months' follow‐up	2	110	Mean Difference (IV, Random, 95% CI)	0.56 [‐0.77, 1.89]
12.4 FACT functional well‐being follow‐up values	9		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.4.1 Up to 12 weeks' follow‐up	7	449	Mean Difference (IV, Random, 95% CI)	1.63 [‐0.43, 3.70]
12.4.2 More than 12 weeks' less than 6 months' follow‐up	2	113	Mean Difference (IV, Random, 95% CI)	0.74 [‐1.03, 2.51]
12.4.3 6 months' follow‐up	2	110	Mean Difference (IV, Random, 95% CI)	0.91 [‐1.02, 2.84]
12.5 QLQ‐C30 role functioning change	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.5.1 Up to 12 weeks' follow‐up	2	73	Mean Difference (IV, Random, 95% CI)	0.42 [‐7.80, 8.65]
12.6 QLQ‐C30 role functioning subscale follow‐up values	5		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.6.1 Up to 12 weeks' follow‐up	4	256	Mean Difference (IV, Random, 95% CI)	7.23 [0.59, 13.87]
12.6.2 More than 12 weeks' less than 6 months' follow‐up	2	150	Mean Difference (IV, Random, 95% CI)	4.63 [‐3.55, 12.80]
12.7 MOS SF‐36 role function subscale change	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.7.1 6 months' follow‐up	1	74	Mean Difference (IV, Random, 95% CI)	‐0.40 [‐5.23, 4.43]
12.8 MOS SF‐36 role function subscale follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.8.1 6 months' follow‐up	1	74	Mean Difference (IV, Random, 95% CI)	0.20 [‐3.71, 4.11]
12.9 CARES marital subscale change	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.9.1 6 months' follow‐up	1	79	Mean Difference (IV, Random, 95% CI)	0.30 [‐2.19, 2.79]
12.10 CARES marital subscale follow‐up values	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.10.1 6 months' follow‐up	1	79	Mean Difference (IV, Random, 95% CI)	0.80 [‐2.00, 3.60]