FIGURE 2.

Plasma concentration‐time curves obtained after administration of docetaxel to Cyp3a^−/− and Cyp3a/Mdr1a/b^−/− mice. Panel A shows plasma concentration‐time curves of oral administration of different doses of docetaxel to Cyp3a^−/− and Cyp3a/Mdr1a/b^−/− mice. Panel B and C show plasma‐concentration‐time curves after oral or intraperitoneal administration of docetaxel to Cyp3a/Mdr1a/b^−/− (panel B) and Cyp3a^−/− (panel C) mice. Inset in panel A, B and C show the AUC_inf. All AUCs_inf differ mutually significantly (P < .001) as calculated with ANOVA of the Log‐transformed data with Bonferroni's post hoc test (panel A) or as calculated with a two‐sided unpaired Student's t test (panel B and C), unless otherwise specified (NS). For all groups n = 5 animals were used (n = 4 for 12.5 mg kg⁻¹ in Cyp3a/Mdr1a/b^−/− mice due to technical problems during administration). Inserts show mean ± standard deviations. Abbreviations: AUC_inf, area under the plasma concentration‐time curves extrapolated from zero to infinity; C _max, maximum plasma concentration; Cyp3a^−/−, Cyp3a knock‐out; Cyp3a/Mdr1a/b^−/−, Cyp3a and P‐glycoprotein knock‐out; NS, not significant