Table 5 – Online.

Linear regression of cumulative anesthesia duration predicting neurocognitive outcomes, models including age at diagnosis and treatment risk arm

Outcome	Model	Variables	Parameter Estimate	SE	T	P (a)	R (2) Adjusted	R (2) Change	F-Value	p (b)
General Intellectual Ability	1	Age at Diagnosis	0.89	0.41	2.15	0.0345	0.05	0.15	18.96	<.0001
		Risk Arm	−4.93	4.14	−1.19	0.2377
	2	Age at Diagnosis	−0.45	0.49	−0.93	0.3566	0.20
		Risk Arm	−0.83	3.90	−0.21	0.8314
		Anesthesia Duration	−0.62	0.14	−4.35	< 0.0001
Broad Attention	1	Age at Diagnosis	0.84	0.43	1.98	0.0507	0.04	0.10	10.61	0.0016
		Risk Arm	−4.58	4.35	−1.05	0.2963
	2	Age at Diagnosis	−0.34	0.54	−0.62	0.5341	0.14
		Risk Arm	−1.27	4.03	−0.30	0.7653
		Anesthesia Duration	−0.54	0.17	−3.26	0.0016
Working Memory	1	Age at Diagnosis	0.66	0.40	1.65	0.102	0.02	0.15	18.09	<.0001
		Risk Arm	−0.32	3.93	−0.82	0.417
	2	Age at Diagnosis	−0.61	0.47	−1.29	0.199	0.17
		Risk Arm	0.21	3.69	0.06	0.9542
		Anesthesia Duration	−0.59	0.14	−4.25	<0.0001
Processing Speed	1	Age at Diagnosis	1.66	0.51	3.26	0.0016	0.09	0.10	11.86	0.0009
		Risk Arm	−0.06	5.21	−0.01	0.9908
	2	Age at Diagnosis	0.31	0.62	0.50	0.6189	0.19
		Risk Arm	3.77	5.04	0.75	0.4565
		Anesthesia Duration	−0.63	0.18	−3.44	0.0009
Broad Reading	1	Age at Diagnosis	0.32	0.36	0.89	0.3765	0.01	0.09	9.87	0.0023
		Risk Arm	−4.57	3.59	−1.27	0.2067
	2	Age at Diagnosis	−0.35	0.40	−0.88	0.3829	0.10
		Risk Arm	−2.48	3.48	−0.71	0.4773
		Anesthesia Duration	−0.39	0.12	−3.14	0.0023

Abbreviations: SE = Standard Error. Bold font = statistically significant at p ≤ 0.05.

^a:2-sided p-value from comparison of parameter estimate to 0.

^b:2-sided p-value from ANOVA comparison of regression models. Anesthesia duration is measured in hours.