Table 6.
Linear regression of cumulative anesthesia duration predicting neurocognitive outcomes, adjustung for age at diagnosis, treatment risk arm, and baseline global intellectual ability
| Outcome | Model | Variables | Parameter Estimate | SE | T | p (a) | R (2) Adjusted | R (2) Change | F-value | p (b) |
|---|---|---|---|---|---|---|---|---|---|---|
| General Intellectual Ability | 1 | Age at Diagnosis | 1.08 | 0.32 | 3.34 | 0.0014 | 0.50 | |||
| Risk Arm | −12.04 | 3.44 | −3.51 | 0.0009 | ||||||
| Baseline IQ | 0.78 | 0.10 | 7.81 | <.0001 | ||||||
| 2 | Age at Diagnosis | 0.04 | 0.39 | 0.11 | 0.9135 | 0.59 | 0.09 | 15.51 | 0.0002 | |
| Risk Arm | −7.04 | 3.34 | −2.11 | 0.0390 | ||||||
| Baseline IQ | 0.71 | 0.09 | 7.77 | <.0001 | ||||||
| Anesthesia Duration | −0.55 | 0.14 | −3.94 | 0.0002 | ||||||
| Broad Attention | 1 | Age at Diagnosis | 0.92 | 0.41 | 2.23 | 0.0293 | 0.21 | |||
| Risk Arm | −9.60 | 4.66 | −2.06 | 0.0440 | ||||||
| Baseline IQ | 0.54 | 0.13 | 4.12 | 0.0001 | ||||||
| 2 | Age at Diagnosis | −0.04 | 0.54 | −0.08 | 0.9367 | 0.29 | 0.09 | 6.93 | 0.0109 | |
| Risk Arm | −5.91 | 4.66 | −1.27 | 0.2100 | ||||||
| Baseline IQ | 0.51 | 0.13 | 4.08 | 0.0001 | ||||||
| Anesthesia Duration | −0.53 | 0.20 | −2.63 | 0.0109 | ||||||
| Working Memory | 1 | Age at Diagnosis | 0.64 | 0.39 | 1.63 | 0.1082 | 0.20 | |||
| Risk Arm | −8.47 | 4.15 | −2.04 | 0.0459 | ||||||
| Baseline IQ | 0.51 | 0.12 | 4.24 | <.0001 | ||||||
| 2 | Age at Diagnosis | −0.46 | 0.49 | −0.94 | 0.3512 | 0.31 | 0.11 | 11.11 | 0.0015 | |
| Risk Arm | −3.53 | 4.12 | −0.86 | 0.3949 | ||||||
| Baseline IQ | 0.43 | 0.11 | 3.84 | 0.0003 | ||||||
| Anesthesia Duration | −0.59 | 0.18 | −3.33 | 0.0015 | ||||||
| Processing Speed | 1 | Age at Diagnosis | 1.99 | 0.36 | 5.52 | <.0001 | 0.41 | |||
| Risk Arm | −7.87 | 4.03 | −1.95 | 0.0554 | ||||||
| Baseline IQ | 0.58 | 0.11 | 5.12 | <.0001 | ||||||
| 2 | Age at Diagnosis | 1.33 | 0.48 | 2.79 | 0.0071 | 0.44 | 0.03 | 4.08 | 0.0480 | |
| Risk Arm | −5.19 | 4.15 | −1.25 | 0.2153 | ||||||
| Baseline IQ | 0.55 | 0.11 | 4.98 | <.0001 | ||||||
| Anesthesia Duration | −0.36 | 0.18 | −2.02 | 0.0480 | ||||||
| Broad Reading | 1 | Age at Diagnosis | 0.48 | 0.31 | 1.54 | 0.1294 | 0.20 | |||
| Risk Arm | −8.55 | 3.36 | −2.55 | 0.0133 | ||||||
| Baseline IQ | 0.39 | 0.10 | 4.06 | 0.0001 | ||||||
| 2 | Age at Diagnosis | −0.11 | 0.41 | −0.27 | 0.7905 | 0.25 | 0.05 | 4.59 | 0.0362 | |
| Risk Arm | −6.20 | 3.44 | −1.80 | 0.0765 | ||||||
| Baseline IQ | 0.34 | 0.10 | 3.61 | 0.0006 | ||||||
| Anesthesia Duration | −0.34 | 0.16 | −2.14 | 0.0362 |
Abbreviations: SE = Standard Error Bold font = statistically significant at p ≤ 0.05.
a:
2-sided p-value from comparison of parameter estimate to 0.
b:
2-sided p-value from ANOVA comparison of regression models. Anesthesia duration is measured in hours.