Table 7 – Online.

Linear regression model of cumulative anesthesia duration predicting neurocognitive outcomes, models including age at diagnosis, treatment risk arm, baseline global intellectual ability and interaction between age at diagnosis and cumulative anesthesia duration

Outcome	Variables	Parameter Estimate	SE	T	p	R (2) Adjusted
General Intellectual Ability	Age at Diagnosis	−0.08	0.49	−0.16	0.8761	0.62
	Risk Arm	−7.07	3.36	−2.10	0.0396
	Baseline IQ	0.71	0.09	7.64	<.0001
	Anesthesia Duration	−0.65	0.29	−2.29	0.0256
	Anesthesia × Age at Diagnosis	0.02	0.04	0.42	0.6786
Broad Attention	Age at Diagnosis	−0.09	0.67	−0.13	0.8966	0.33
	Risk Arm	−5.87	4.71	−1.25	0.2181
	Baseline IQ	0.51	0.13	4.03	0.0002
	Anesthesia Duration	−0.57	0.40	−1.43	0.1578
	Anesthesia Duration × Age at Diagnosis	0.01	0.06	0.11	0.9096
Working Memory	Age at Diagnosis	−0.64	0.61	−1.05	0.2996	0.36
	Risk Arm	−3.62	4.15	−0.87	0.3874
	Baseline IQ	0.44	0.12	3.84	0.0003
	Anesthesia Duration	−0.74	0.35	−2.08	0.0418
	Anesthesia Duration × Age at Diagnosis	0.02	0.05	0.49	0.6241
Processing Speed	Age at Diagnosis	1.62	0.59	2.75	0.0080	0.48
	Risk Arm	−5.42	4.17	−1.30	0.1980
	Baseline IQ	0.54	0.11	4.85	<.0001
	Anesthesia Duration	−0.10	0.35	−0.29	0.7731
	Anesthesia Duration × Age at Diagnosis	−0.04	0.05	−0.84	0.4050
Broad Reading	Age at Diagnosis	−0.30	0.52	−0.58	0.5648	0.30
	Risk Arm	−6.32	3.46	−1.82	0.0731
	Baseline IQ	0.35	0.10	3.64	0.0006
	Anesthesia Duration	−0.51	0.33	−1.56	0.1252
	Anesthesia Duration × Age at Diagnosis	0.02	0.04	0.60	0.5506

Abbreviations: SE = Standard Error. Bold font = statistically significant at p ≤ 0.05. 2-sided p-value from comparison of parameter estimate to 0. Anesthesia duration is measured in hours