Table 2.
Odds ratios of risk factors associated with colorectal cancer risk stratified by sex
| Cases n(%)/Controls n(%) | OR (95% CI) | |||
|---|---|---|---|---|
| Men | Women | Men | Women | |
| Healthy lifestyle score | ||||
| Unfavourable lifestyle | 1013(39)/590(29) | 308(19)/142(11) | 1.00 (Ref.) | 1.00 (Ref.) |
| Intermediate lifestyle | 931(36)/746(36) | 573(35)/383(30) | 0.78 (0.67–0.90) | 0.72 (0.57–0.93) |
| Favourable lifestyle | 640(25)/726(35) | 755(46)/751(59) | 0.55 (0.47–0.64) | 0.50 (0.40–0.63) |
| Polygenic risk score | ||||
| Low genetic risk | 555(21)/699(34) | 346(21)/415(33) | 1.00 (Ref.) | 1.00 (Ref.) |
| Intermediate genetic risk | 851(33)/699(34) | 517(32)/439(34) | 1.54 (1.32–1.80) | 1.45 (1.19–1.77) |
| High genetic risk | 1178(46)/664(32) | 773(47)/422(33) | 2.24 (1.93–2.62) | 2.23 (1.84–2.70) |
| Colonoscopy in the preceding 10 years | ||||
| No | 1888(73)/989(48) | 1192(73)/649(51) | 1.00 (Ref.) | 1.00 (Ref.) |
| Yes | 696(27)71073(52) | 444(27)7627(49) | 0.34 (0.30–0.39) | 0.38 (0.32–0.44) |
Abbreviations: OR, odds ratio; CI, confidence interval;
1
The logistic regression models included age, healthy lifestyle score, polygenic risk score and colonoscopy in the preceding 10 years