(A, C, E, G) Overall survival (OS) did not significantly
differ between patients grouped by OX40 (A) or PD-1
(C) levels only. Among patients with high OX40 expression
(E), patients with low PD-1 lived significantly longer than did
those with high PD-1. Among patients with low PD-1 expression (G),
patients with high OX40 lived significantly longer than did those with low
OX40.
(B, D, F, G) Disease-free survival (DFS) was significantly
longer in patients with high OX40 than in those with low OX40 (B).
There were no differences in DFS in other comparisons; however, tails on the
survival curves were elevated in patients with low PD-1 compared with patients
with high PD-1 in both the whole population (D) and in the
subpopulation with high OX40 (F). Among patients with low PD-1
(H), the tail was elevated in patients with high OX40.