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. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Ann Allergy Asthma Immunol. 2020 Mar 27;125(2):190–195.e2. doi: 10.1016/j.anai.2020.03.018

Table 2:

Distribution of Patients (N, %) with IgG or IgG Subclass Concentrations Above or Below Reference Ranges According to Sex and Race

	Sex		Race

IgG Subclass	Female (N=7,917)	Male (N=4,934)	Asian (N = 302)	Black (N=611)	White (N= 11,673)	Overall (N = 12,851)
IgG
> ULN (N, %)	747 (9.4%)	490 (9.9%)	68 (22.5%)	209 (34.2%)	907 (7.8%)^*	1237 (9.6%)
< LLN (N, %)	1142 (14.4%)	847 (17.2%)^*	16 (5.3%)	25 (4.1%)	1922 (16.5%)^*	1989 (15.5%)

IgG1
> ULN (N, %)	673 (8.5%)	463 (9.4%)	61 (20.2%)	198 (32.4%)	822 (7.0%)^*	1136 (8.8%)
< LLN (N, %)	1428 (18.0%)	1012 (20.5%)^*	24 (8.0%)	31 (5.1%)	2356 (20.2%)^*	2440 (19.0%)

IgG2
> ULN (N, %)	271 (3.4%)	200 (4.1%)	52 (17.2%)	48 (7.9%)	355 (3.0%)^*	471 (3.7%)
< LLN (N, %)	1883 (23.8%)	1181 (23.9%)	24 (8.0%)	104 (17.0%)	2891 (24.8%)^*	3064 (23.8%)

IgG3
> ULN (N, %)	394 (5.0%)	297 (6.0%)^*	34 (11.3%)	84 (13.8%)	551 (4.7%)^*	691 (5.4%)
< LLN (N, %)	949 (12.0%)	653 (13.2%)^*	30 (10.0%)	28 (4.6%)	1520 (13.0%)^*	1602 (12.5%)

IgG4
> ULN (N, %)	483 (6.1%)	517 (10.5%)^*	75 (24.8%)	73 (12.0%)	819 (7.0%)^*	1000 (7.8%)
< LLN (N, %)	744 (9.4%)	425 (8.6%)	10 (3.3%)	37 (6.1%)	1106 (9.5%)^*	1169 (9.9%)

^*

p < 0.05