Table 1. RNA binding proteins predicted to interact with SMN circRNAs.
(A)Experimentally validated RBPs shown to interact with SMN sequences present in circRNAs. RBP name, SMN exon bound, and major circRNA isoforms that contain the target exon are given. Original studies identifying the RBP-SMN interaction are given in the ‘Reference’ column. (B)RBPs identified by CLIP and reported in public databases. The first three columns are the same as in (A). The fourth column lists the database(s) reporting CLIP tags.
| Table 1A. Experimentally validated RNA binding proteins | |||
|---|---|---|---|
| Protein | Exon | circRNAs | Reference |
| SF2/ASF (SRSF1) | 7 | Type 3 (all) | [84] |
| hnRNP A1/A2B1 | 7 | Type 3 (all) | [85] |
| Sam68 | 7 | Type 3 (all) | [86] |
| hnRNP Q | 7 | Type 3 (all) | [87] |
| Tra2-β | 7 | Type 3 (all) | [88,89] |
| hnRNP G | 7 | Type 3 (all) | [90] |
| hnRNP M | 7 | Type 3 (all) | [91] |
| PSF | 7 | Type 3 (all) | [92] |
| Table 1B. RNA binding proteins identified by CLIP | |||
| Protein | Exon | circRNAs | Database |
| FUS | 2B | C2A–2B–3–4, C2B–3–4 | CircInteractome, starBase |
| TAF15 | 2B, 7 | C2A–2B–3–4, C2B–3–4, Type 3 (all) | starBase |
| IGF2BP2 | All exons | All circRNA | starBase |
| AGO1 | 3, 5 | Type 1 (all), Type 2 (all) | CircInteractome |
| SF2/ASF (SRSF1) | 3, 4, 5, 7, 8A | Type 1 (all), Type 2 (all) | starBase |
| SRSF3 | 3, 4, 5, 8A | Type 1 (all), Type 2 (all) | starBase |
| MOV10 | 3, 8A | Type 1 (all), Type 3 (all) | starBase |
| U2AF2 | 4, 5, 7 | Type 1 (all), Type 2 (all) | starBase |
| YTHDC1 | 4, 8A | Type 1 (all), Type 3 (all) | starBase |
| EIF4A3 | 5 | Type 2 (all) | circInteractome, starBase |
| LIN28 | 6 | Type 2 (all), Type 3 (all) | circInteractome, starBase |
| hnRNP U | 6, 7 | Type 2 (all), Type 3 (all) | starBase |
| TARDBP | 6, 7 | Type 2 (all), Type 3 (all) | starBase |
| ILF3 | 6 | Type 2 (all), Type 3 (all) | starBase |
| KHDRBS1 | 7 | Type 3 (all) | starBase |