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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Stroke. 2020 Jul 22;51(8):2454–2463. doi: 10.1161/STROKEAHA.120.029123

Table 1.

COMPASS Ischemic Stroke Suggestive and Genome-wide Significant Inverse Variance Weighted Associations

Chr Position* Gene SNP Alleles (Coded/ Noncoded) Beta Standard Error Odds Ratio (Confidence Interval) Inverse Variance Weighted P-Value Direction Het P Value Sample Size Number of Studies
1 112853017 CTTNBP2NL (nearest) rs114947355 T/C 0.44 0.0902 1.56 (1.42–1.70) 9.05×10−07 ????-+?+??? 0.1382 12610 3
1 112857084 CTTNBP2NL (nearest) rs147779128 A/T −0.46 0.0945 0.63 (0.57–0.69) 9.61×10−07 ?????-?-??? 0.9293 9637 2
2 4083658 NPM1P48 (nearest) rs142655108 A/C 0.58 0.1089 1.79 (1.60–1.99) 9.52×10−08 ?????+?+??? 0.2834 9637 2
2 198551159 RFTN2 and MARS2 (nearest) rs115670077 T/G 0.35 0.072 1.43 (1.33–1.53) 8.48×10−07 +?++++?+??? 0.5735 16540 6
3 124048486 KALRN rs72976591 A/C 0.17 0.0342 1.18 (1.14–1.22) 9.19×10−07 +++++++++++ 0.5356 22018 11
3 133101791 TMEM108 rs113509723 -/AA 0.45 0.0841 1.58 (1.45–1.71) 6.46×10−08 ?????+?+??? 0.2014 9637 2
3 153125290 AK092619 (nearest) rs184221467 A/G 0.62 0.1246 1.85 (1.63–2.10) 7.86×10−07 ?????+?+??? 0.468 9637 2
4 99435032 TSPAN5 rs138134155 A/G 0.36 0.0705 1.43 (1.33–1.53) 3.94×10−07 +?++++?++?? 0.9442 18531 7
5 101123995 OR7H2P (nearest) rs77460585 A/G 0.59 0.1165 1.80 (1.60–2.02) 4.36×10−07 ????-??+??? 0.004981 10940 2
5 150981704 FAT2 and SPARC (nearest) rs114527838 A/G −0.28 0.055 0.76 (0.72–0.80) 5.55×10−07 -?-------?? 0.7033 19032 8
6 97345991 KLHL32 and NDUFA4 (nearest) rs146522546 -/CT −0.45 0.0876 0.64 (0.58–0.69) 2.22×10−07 ???—?-??? 0.3829 13353 4
7 83432409 SEMA3A rs6967981 T/G 0.15 0.0296 1.16 (1.12–1.19) 7.57×10−07 +-++++++++- 0.1685 21970 11
8 1572874 DLGAP2 rs112455974 A/C 0.68 0.1336 1.97 (1.72–2.25) 3.77×10−07 ????+??+??? 0.7366 10949 2
9 72475192 C9orf135 rs565295967 T/C 0.62 0.1199 1.86 (1.65–2.09) 2.41×10−07 ?????+?+??? 0.1048 9637 2
10 53545098 PRKG1 rs140164788 T/C 0.52 0.1019 1.68 (1.52–1.86) 3.37×10−07 ????++?+??? 0.7146 12618 3
10 53547264 PRKG1 rs74469072 T/G 0.52 0.1018 1.68 (1.52–1.86) 3.50×10−07 ????++?+??? 0.7169 12618 3
10 120907173 SFXN4 rs150807690 -/G −0.20 0.0378 0.82 (0.79–0.85) 9.67×10−08 ?-?---?---- 0.3014 18180 8
11 11360296 GALNT18 rs115825287 T/C 0.35 0.0696 1.43 (1.33–1.53) 3.60×10−07 ??++++?+??? 0.6076 15673 5
11 75683895 UVRAG rs368167310 T/C −0.55 0.1085 0.58 (0.52–0.65) 4.87×10−07 ?????-?-??? 0.8172 9637 2
12 29288407 FAR2 (nearest) rs113025543 A/T −0.27 0.0551 0.76 (0.72–0.81) 9.23×10−07 -+--------? 0.7896 20224 10
12 29292793 FAR2 (nearest) rs142100833 C/G 0.24 0.0488 1.27 (1.21–1.34) 8.65×10−07 +-+++++++-? 0.4482 20119 10
12 29341407 FAR2 - -/?? 0.65 0.1272 1.91 (1.68–2.17) 3.79×10−07 ???++???+?? 0.9784 5542 3
12 119502791 SRRM4 rs531465435 -/C 0.59 0.1162 1.81 (1.61–2.03) 3.39×10−07 ?????+?+??? 0.5809 9637 2
12 119542751 SRRM4 rs192977447 A/T 0.43 0.0816 1.53 (1.41–1.66) 1.80×10−07 ???+++?++?? 0.1962 15333 5
12 121415209 HNF1A (nearest) rs55931441 A/G 0.52 0.0947 1.68 (1.53–1.84) 4.62×10−08 ?????+?+??? 0.4599 9637 2
14 93788855 BTBD7 rs113949028 -/G 0.20 0.0396 1.22 (1.17–1.27) 5.44×10−07 ?+?+++?++++ 0.948 18255 8
18 68475060 GTSCR1 (nearest) rs181095590 A/G 0.58 0.1138 1.78 (1.59–2.00) 3.90×10−07 ?????+?+??? 0.4538 9637 2
19 29710081 UQCRFS1 (nearest) rs73923591 A/G 0.27 0.0548 1.31 (1.24–1.39) 6.18×10−07 ++++++++++? 0.8774 20246 10
21 36442465 RUNX1 rs116262092 A/T −0.58 0.1174 0.56 (0.50–0.63) 7.04×10−07 ????–?-??? 0.9789 12581 3
21 36443919 RUNX1 rs147867382 C/G −0.58 0.1174 0.56 (0.50–0.63) 7.95×10−07 ????–?-??? 0.9792 12579 3

Chromosome (Chr) Position based on Human Genome (GRCh37/hg19)

Direction indicates the direction of the effect size: negative (−), neutral/unknown (./?), and positive (+) for each contributing cohort/population