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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Gastroenterology. 2020 Jun 24;159(1):289–305.e16. doi: 10.1053/j.gastro.2020.03.013

Figure 6. Levels of p-ABL1, c-MYC or NOTCH1 are positively correlated in human HCC.

Figure 6.

(A) A schematic model: ABL1 activation (due to ABL1 overexpression or other reasons) leads to an increase of c-MYC protein expression and its transcriptional activity with respect to NOTCH1, thereby promoting HCC cell proliferation. (B) Levels of p-ABL1 (p-Y412), c-MYC and NOTCH1 in human HCC specimens (TMA) were determined by IHC staining. (C) Correlation of p-ABL1 and c-MYC levels in human HCC specimens was analyzed. (D) Correlation of p-ABL1 and NOTCH1 levels in human HCC specimens was analyzed. (E) Correlation of c-MYC and NOTCH1 expression in human HCC specimens was analyzed. (F) Correlation of ABL1 and NOTCH1 mRNAs in HCC samples from the TCGA database was analyzed.