Table 1.
Isotopic labeling employed for the 150 kDa oligomer samples analyzed in this study.
| Sample | Isotopic Labeling |
|---|---|
| Uniform 13C-labeling and 15N- labeling at the indicated residues: | |
| 1 | K16, F20, V24, G37 |
| 2 | D7, G9, E11.L17, F19, A21 |
| 3 | E11, F19, 131, V36 |
| 4 | E11.L17.A21, M35, G38 |
| 5 | I32, M35, G37, V40 |
| 6 | Q15, V18, A21 |
| 7 | S8, Y10, V12, L34, G38, 141 |
| 8 | V12, E22, S26, N27, G33 |
| 9 | V12, F20, D23, K28, G29 |
| 10 | E11, H13, Q15, L17 |
| 11 | E11, K16, F19, V36 |
| 12 | A2, E3, F4, G9, V39 |
| 13 | H14, K16, L34, A42 |
| 14 | F19, V24, G25, A30, 131, L34, M35 [33] |
| Selective 13C-labeling at the indicated sites: | |
| A | L17 CO |
| B | V18 CO |
| C | F19 CO |
| D | F20 CO |
| E | A21 CO |
| F | L17 CO and F19 CO |
| G | V18COandA21 CO |
| H | L17 CO and A21 CO |
| I | V18 CO and A21 CO (50% isotope-diluted) |