| Study characteristics |
| Methods |
Randomized, placebo‐controlled |
| Participants |
Any cardiothoracic surgery (randomization stratified by CABG vs valve) |
| Interventions |
Amiodarone vs. Bachmann's Bundle Pacing vs. placebo |
| Outcomes |
AF; LOS; Cost |
| Follow‐Up |
Hospital discharge, 1 week postop, 1 month postop |
| Concurrent Antiarrhythmic Medications |
Beta‐blockers |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
|
| Allocation concealment (selection bias) |
Unclear risk |
Concealment methods not described |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
"This study was designed as a management trial in that the recommended treatment regimens were established by study investigators and available to clinicians but the patient's physician determined whether to adjust regimen intensity or to discontinue therapy without investigator consultation" |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
"This study was designed as a management trial in that the recommended treatment regimens were established by study investigators and available to clinicians but the patient's physician determined whether to adjust regimen intensity or to discontinue therapy without investigator consultation" |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
|
| Selective reporting (reporting bias) |
Low risk |
|
| Intention‐to‐treat analysis |
Unclear risk |
Not reported |
