| Study characteristics |
| Methods |
Double‐blind, randomized, controlled |
| Participants |
Elective on‐pump CABG only |
| Interventions |
Magnesium vs. Control |
| Outcomes |
AF; Mortality; CV Mortality |
| Follow‐Up |
3 days |
| Concurrent Antiarrhythmic Medications |
Beta‐blockers |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"Patients were allocated to one of two groups by random numbers generated from random‐number tables" |
| Allocation concealment (selection bias) |
Low risk |
"Patients were allocated to one of two groups by random numbers generated from random‐number tables" |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
"To administer magnesium sulfate on the basis of ionized magnesium plasma levels and repeat this intervention as required, one nominated investigator remained unblinded to treatment group. All other clinicians involved in the care of patients and technicians concerned with the analysis of Holter tapes were rigorously blinded throughout the study period." |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
"To administer magnesium sulfate on the basis of ionized magnesium plasma levels and repeat this intervention as required, one nominated investigator remained unblinded to treatment group. All other clinicians involved in the care of patients and technicians concerned with the analysis of Holter tapes were rigorously blinded throughout the study period." |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
"Another two patients underwent mediastinal reexploration for bleeding complications (one in each group). All of these patients were excluded from further analysis of postoperative cardiac rhythm" |
| Selective reporting (reporting bias) |
Unclear risk |
Protocol not available |
| Intention‐to‐treat analysis |
Unclear risk |
Not reported |
