Zebis 2007.

Study characteristics
Methods	Double‐blind, randomized, placebo‐controlled
Participants	On‐pump CABG only; Randomization stratified by age (65 yrs) and pre‐op use of Beta‐blockers
Interventions	Amiodarone vs. placebo
Outcomes	AF; Stroke; Mortality
Follow‐Up	5 days
Concurrent Antiarrhythmic Medications	Beta‐blockers
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Computerized prospective randomization schedule"
Allocation concealment (selection bias)	Low risk	"Each patient received a randomization number, which was recorded and sent by fax to the pharmacy... The pharmacy decoded the randomization number, prepared the appropriate infusion and pills, and forwarded them, together with a sealed opaque envelope containing the randomization assignment..."
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	High risk	Intention‐to‐treat analysis stated, but not reported
Selective reporting (reporting bias)	Unclear risk	Protocol not available
Intention‐to‐treat analysis	High risk	No

ACE: angiotensin‐converting enzyme
AF: atrial fibrillation
AVNRT: atrioventricular nodal reentry tachycardia
AVR: aortic valve replacement
bpm: beats per minute
CABG: coronary artery bypass graft
CCBs: calcium channel blockers
CV: cardiovascular
ICU: intensive care unit
LOS: length of stay
SVT: supraventricular tachycardia
tid: three times per day