Table 4:

Associations of time-updated cumulative NSAID and opioid exposure with outcomes, adjusting for time-dependent covariates in the full cohort and a sub-cohort comprised of participants who ever used other analgesics or tramadol during CRIC study

Outcome	Full cohort		Sub-cohort
	HR* (95% CI)	P value	HR* (95% CI)	P value
Composite kidney disease outcome**
Opioid use	1.4 (1.2, 1.7)	<0.001	1.6 (1.3, 2.0)	<0.001
NSAID use	1.2 (1.0, 1.5)	0.04	1.1 (0.9, 1.4)	0.2
Kidney failure with KRT
Opioid use	1.4 (1.1, 1.7)	0.005	1.5 (1.2, 2.0)	<0.001
NSAID use	1.1 (0.8, 1.3)	0.6	1.0 (0.7, 1.3)	0.9
Pre-kidney failure death
Opioid use	1.5 (1.2, 2.0)	0.002	1.6 (1.1, 2.2)	0.009
NSAID use	0.9 (0.7, 1.1)	0.3	1.2 (0.8, 1.7)	0.5
Hospitalization
Opioid use	1.7 (1.6, 1.9)	<0.001	1.7 (1.5, 1.9)	<0.001
NSAID use	1.1 (1.0, 1.3)	0.01	1.1 (0.9, 1.3)	0.08

Other analgesics are non-opioid, non-NSAID.