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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Comparison 20. Ephedrine: different doses.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
20.1 Women with hypotension requiring intervention 6   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.1.1 5 mg vs 10 mg 2 100 Risk Ratio (M‐H, Random, 95% CI) 1.05 [0.65, 1.69]
20.1.2 6 mg vs 12 mg 1 46 Risk Ratio (M‐H, Random, 95% CI) 1.83 [0.83, 4.04]
20.1.3 5 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.94, 4.27]
20.1.4 10 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.83 [0.84, 3.99]
20.1.5 10 mg vs 20 mg 2 60 Risk Ratio (M‐H, Random, 95% CI) 1.06 [0.80, 1.39]
20.1.6 10 mg vs 30 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.43 [1.30, 4.54]
20.1.7 15 mg vs 30 mg 1 100 Risk Ratio (M‐H, Random, 95% CI) 2.11 [1.06, 4.21]
20.1.8 20 mg vs 30 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.29 [1.21, 4.32]
20.2 Women with hypertension requiring intervention 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.2.1 5 mg vs 10 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.20 [0.44, 3.30]
20.2.2 5 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.50 [0.23, 1.07]
20.2.3 10 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.42 [0.18, 0.96]
20.2.4 10 mg vs 20 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.20 [0.03, 1.56]
20.2.5 10 mg vs 30 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.11 [0.02, 0.80]
20.2.6 20 mg vs 30 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.56 [0.23, 1.37]
20.3 Women with nausea and/or vomiting 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.3.1 6 mg vs 12 mg (nausea and/or vomiting) 1 46 Risk Ratio (M‐H, Random, 95% CI) 0.81 [0.38, 1.74]
20.3.2 5 mg vs 10 mg (vomiting) 1 40 Risk Ratio (M‐H, Random, 95% CI) 3.00 [0.34, 26.45]
20.3.3 5 mg vs 15 mg (vomiting) 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.50 [0.28, 8.04]
20.3.4 10 mg vs 15 mg (vomiting) 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.50 [0.05, 5.08]
20.3.5 5 mg vs 10 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.83, 4.81]
20.3.6 5 mg vs 15 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.50 [0.94, 6.66]
20.3.7 10 mg vs 15 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.25 [0.39, 3.99]
20.3.8 10 mg vs 20 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.69 [0.39, 1.24]
20.3.9 10 mg vs 30 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.80 [0.73, 4.43]
20.3.10 15 mg vs 30 mg (nausea) 1 100 Risk Ratio (M‐H, Random, 95% CI) 1.43 [0.59, 3.45]
20.3.11 20 mg vs 30 mg (nausea) 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.60 [1.14, 5.93]
20.3.12 15 mg vs 30 mg (vomiting) 1 100 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.12, 3.82]
20.4 Neonates with acidosis (pH < 7.2) 3   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.4.1 5 mg vs 10 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.20 [0.01, 3.92]
20.4.2 5 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 7.72]
20.4.3 6 mg vs 12 mg 1 46 Risk Ratio (M‐H, Random, 95% CI) 0.31 [0.01, 7.16]
20.4.4 10 mg vs 15 mg 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.00 [0.20, 20.33]
20.4.5 10 mg vs 20 mg 1 39 Risk Ratio (M‐H, Random, 95% CI) 0.59 [0.24, 1.50]
20.4.6 10 mg vs 30 mg 1 38 Risk Ratio (M‐H, Random, 95% CI) 1.12 [0.36, 3.55]
20.4.7 20 mg vs 30 mg 1 37 Risk Ratio (M‐H, Random, 95% CI) 1.89 [0.69, 5.21]
20.5 Neonatal Apgar score at 5 min 4   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
20.5.1 6 mg vs 12 mg (Apgar < 7) 1 46 Risk Ratio (M‐H, Random, 95% CI) 0.31 [0.01, 7.16]
20.5.2 5 mg vs 10 mg (Apgar < 8) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.3 5 mg vs 15 mg (Apgar < 8) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.4 10 mg vs 15 mg (Apgar < 8) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.5 10 mg vs 20 mg (Apgar < 7) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.6 10 mg vs 30 mg (Apgar < 7) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.7 20 mg vs 30 mg (Apgar < 7) 1 40 Risk Ratio (M‐H, Random, 95% CI) Not estimable
20.5.8 10 mg vs 20 mg (Apgar < 8) 1 20 Risk Ratio (M‐H, Random, 95% CI) Not estimable