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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Faydaci 2011.

Study characteristics
Methods RCT
Participants 90 women
Inclusion criteria: ASA1‐2, elective CS under SAB
Exclusion criteria: not stated
Setting: Turkey
Interventions Crystalloid preload: different doses
Group 1: 10 mL/kg Ringer's lactate
Group 2: 15 mL/kg Ringer's lactate
Group 3: 20 mL/kg Ringer's lactate
All preloads administered over 15 min before SAB with subsequent ephedrine infusion commenced immediately after SAB
All women received standardised premedication/fasting, spinal dose and technique, position, monitoring
Hypotension was treated with 10 mg IV bolus ephedrine
Outcomes Maternal: incidence of hypotension, nausea and vomiting, total amount ephedrine
Neonatal: cord blood gas analysis, Apgars at 1 min and 5 min
Notes Hypotension defined as decrease in MAP of > 20%
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random numbers
Allocation concealment (selection bias) Low risk "Enclosed system" presumably means covered
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not reported
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Not reported
Selective reporting (reporting bias) Low risk Not apparent
Other bias Low risk Not apparent