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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

French 1999.

Study characteristics
Methods RCT
Participants 160 women
Inclusion criteria: ASA I or II undergoing elective caesarean under spinal anaesthesia
Interventions Colloid preload versus crystalloid preload
Group 1: pentastarch 10% in 0.9% saline 15 mL/kg
Group 2: Hartmann's solution 15 mL/kg
All women received a standardised anaesthetic technique with variable anaesthetic dose, followed by standardised surgical positioning.
Outcomes Maternal: BP; hypotension; block height; uterine incision to birth interval
Neonatal: Apgar scores at 1 min and 5 min; cord pH
Notes Hypotension was defined as SBP below 90 mmHg or < 70% below baseline.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomisation method not described
Allocation concealment (selection bias) Low risk Adequate: randomisation code by pharmacy and study drugs "covered with a black plastic bag to ensure blinding"
Blinding of participants and personnel (performance bias)
All outcomes Low risk Blinding: not specifically stated but anaesthetist and women presumably were blinded
Blinding of outcome assessment (detection bias)
All outcomes Low risk As above
Incomplete outcome data (attrition bias)
All outcomes Low risk Not reported
Selective reporting (reporting bias) Low risk None apparent
Other bias Low risk None apparent