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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Jorgensen 2000.

Study characteristics
Methods RCT
Participants 120 women
Exclusion criteria: pre‐eclampsia, arterial hypertension or multiple pregnancy
Setting: Denmark
Interventions Warm versus cold crystalloid preload
Group 1: cold (21 degrees centigrade 0.9% saline preload)
Group 2: warm (37 degrees centigrade saline preload)
All women received a standardised spinal anaesthetic technique and dose as well as 5 mg IV ephedrine after spinal injection.
Outcomes Maternal: hypotension; heart rate; arm discomfort; shivering; nausea; vomiting
Notes Hypotension was defined as < 70% decrease in SAP from baseline or 100 mmHg or less.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomisation: "computer generation"
Allocation concealment (selection bias) Unclear risk Allocation concealment: "sealed envelopes"
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Blinding: not double‐blinded
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Blinding: not double‐blinded
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Losses to follow‐up: 7/120 women were withdrawn from study, 2 because of failed spinal anaesthesia, 1 because of violation of selection criteria, and 5 because of protocol violations
Selective reporting (reporting bias) Low risk None apparent
Other bias Low risk None apparent