Kohler 2002.
Study characteristics | ||
Methods | RCT | |
Participants | 100 women Inclusion criteria: healthy women (ASA I or II) scheduled for elective CS under spinal anaesthesia Exclusion criteria: pre‐eclampsia, arterial hypertension, gestational age less than 38 weeks or multiple pregnancy |
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Interventions |
Supine versus sitting positioning after spinal anaesthesia Group 1: modified supine (tilted 10 degrees to left) after spinal Group 2: sitting position for 3 min after spinal before modified supine (n = 52) All women received 200‐300 mL isotonic saline given before spinal, then an additional 15 mL/kg after a standardised spinal anaesthetic technique and dose. |
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Outcomes |
Maternal: hypotension; BP; nausea; vomiting; pain; level of anaesthesia; rescue with ephedrine; time from injection to birth; time from incision to birth Neonatal: umbilical arterial and venous blood; Apgar scores at 1 min and 5 min; time to sustained respiration; birthweight |
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Notes | Hypotension was defined as SBP < 70% of baseline or < 100 mmHg | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated codes |
Allocation concealment (selection bias) | Low risk | Adequate: "assignments were kept in sealed sequentially‐numbered opaque envelopes" |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Blinding: not mentioned |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Blinding: "haemodynamic data were transferred to a database by a person blind to which group the woman had been allocated" |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Losses to follow‐up: 2/100 – 1 because of electrical power failure and 1 because of violation of selection criteria |
Selective reporting (reporting bias) | Low risk | None apparent |
Other bias | Low risk | None apparent |