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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Kohler 2002.

Study characteristics
Methods RCT
Participants 100 women
Inclusion criteria: healthy women (ASA I or II) scheduled for elective CS under spinal anaesthesia
Exclusion criteria: pre‐eclampsia, arterial hypertension, gestational age less than 38 weeks or multiple pregnancy
Interventions Supine versus sitting positioning after spinal anaesthesia
Group 1: modified supine (tilted 10 degrees to left) after spinal
Group 2: sitting position for 3 min after spinal before modified supine (n = 52)
All women received 200‐300 mL isotonic saline given before spinal, then an additional 15 mL/kg after a standardised spinal anaesthetic technique and dose.
Outcomes Maternal: hypotension; BP; nausea; vomiting; pain; level of anaesthesia; rescue with ephedrine; time from injection to birth; time from incision to birth
Neonatal: umbilical arterial and venous blood; Apgar scores at 1 min and 5 min; time to sustained respiration; birthweight
Notes Hypotension was defined as SBP < 70% of baseline or < 100 mmHg
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated codes
Allocation concealment (selection bias) Low risk Adequate: "assignments were kept in sealed sequentially‐numbered opaque envelopes"
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Blinding: not mentioned
Blinding of outcome assessment (detection bias)
All outcomes Low risk Blinding: "haemodynamic data were transferred to a database by a person blind to which group the woman had been allocated"
Incomplete outcome data (attrition bias)
All outcomes Low risk Losses to follow‐up: 2/100 – 1 because of electrical power failure and 1 because of violation of selection criteria
Selective reporting (reporting bias) Low risk None apparent
Other bias Low risk None apparent