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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Lin 1999.

Study characteristics
Methods RCT
Participants 60 women
Inclusion criteria: healthy parturients undergoing primary or repeat CS, gestation 33‐41 weeks, uncomplicated singleton, not in labour, ASA I
Interventions Colloid preload versus crystalloid preload
Group 1: 500 mL dextran 40 (n = 30)
Group 2: 1000 mL Ringer's lactate (n = 30)
Study drug administered over 20 min prior to spinal
All women received a standardised spinal anaesthetic technique with variable dose (1.8‐2.2mL 0.5% bupivacaine).
Outcomes Maternal: hypotension; uterine incision‐delivery time; estimated blood loss; urine output; nausea
Neonatal: Apgar scores at 1 min and 5 min
Notes Hypotension defined as SBP < 70% baseline
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method not described
Allocation concealment (selection bias) Unclear risk Method not described
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Blinding not mentioned
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Blinding not mentioned
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Losses to follow‐up: not stated
Selective reporting (reporting bias) Unclear risk Not reported
Other bias Unclear risk Not apparent