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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Loke 2002.

Study characteristics
Methods RCT
Participants 40 women
Inclusion criteria: ASA I women presenting for elective caesarean under spinal anaesthesia
Interventions Head‐down tilt versus control:
Group 1: anaesthesia induced in right lateral position (woman's spine inclined at 5 to 6 degrees from horizontal with head slightly lower); anaesthesia induced in right lateral position 10 degree head‐up tilt
Group 2: anaesthesia induced in right lateral position (woman's spine inclined at 4 to 5 degrees from horizontal with head slightly higher).
All women received a standardised preload of 1 litre crystalloid IV and a standardised spinal anaesthetic technique and dose.
Outcomes Maternal: hypotension; sensory block; ephedrine requirement; nausea; pain
Neonatal: Apgar scores at 1 min and 5 min
Notes Hypotension defined as SBP < 90 mmHg
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method not described
Allocation concealment (selection bias) Unclear risk "Sealed envelope method"
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not mentioned
Blinding of outcome assessment (detection bias)
All outcomes Low risk Blinding: outcome assessors were only admitted to the operating room once the position of the operating table had been readjusted
Incomplete outcome data (attrition bias)
All outcomes Low risk Losses to follow‐up: none reported but losses unlikely
Selective reporting (reporting bias) Low risk None apparent
Other bias Low risk None apparent