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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Madi‐Jebara 2008.

Study characteristics
Methods RCT
Participants 120 women
Inclusion criteria: non‐labouring ASA I and II women having non‐urgent CS
Exclusion criteria: obesity (> 115 kg), height < 152 cm, diabetes, pregnancy‐induced hypertension, chronic hypertension, heart disease, multiple gestation, age < 18 or > 40 years
Setting: Lebanon
Interventions Colloid versus crystalloid
Group 1: HES (500 mL)
Group 2: Ringer's lactate (1000 mL)
All women received study fluid administered as preload before spinal. No IV fluids were administered prior to anaesthesia. Standardised spinal anaesthetic technique and dose. Hypotension (requiring intervention) received IV boluses of 3 mg ephedrine; repeated every 2 min if hypotension persisted or recurred
Outcomes Maternal: hypotension; nausea and/or vomiting
Neonatal: Apgar scores; umbilical arterial and venous pH
Notes Hypotension defined as SBP < 100 mmHg or 20% decrease from baseline.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "Randomly assigned" – no further details given
Allocation concealment (selection bias) Unclear risk As above
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not reported
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias)
All outcomes Low risk No losses to follow‐up
Selective reporting (reporting bias) Unclear risk None of the neonatal outcomes were reported in a form that could be used in this review.
Other bias Low risk Baseline characteristics were similar.