Madi‐Jebara 2008.
Study characteristics | ||
Methods | RCT | |
Participants | 120 women Inclusion criteria: non‐labouring ASA I and II women having non‐urgent CS Exclusion criteria: obesity (> 115 kg), height < 152 cm, diabetes, pregnancy‐induced hypertension, chronic hypertension, heart disease, multiple gestation, age < 18 or > 40 years Setting: Lebanon |
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Interventions |
Colloid versus crystalloid Group 1: HES (500 mL) Group 2: Ringer's lactate (1000 mL) All women received study fluid administered as preload before spinal. No IV fluids were administered prior to anaesthesia. Standardised spinal anaesthetic technique and dose. Hypotension (requiring intervention) received IV boluses of 3 mg ephedrine; repeated every 2 min if hypotension persisted or recurred |
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Outcomes |
Maternal: hypotension; nausea and/or vomiting Neonatal: Apgar scores; umbilical arterial and venous pH |
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Notes | Hypotension defined as SBP < 100 mmHg or 20% decrease from baseline. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "Randomly assigned" – no further details given |
Allocation concealment (selection bias) | Unclear risk | As above |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No losses to follow‐up |
Selective reporting (reporting bias) | Unclear risk | None of the neonatal outcomes were reported in a form that could be used in this review. |
Other bias | Low risk | Baseline characteristics were similar. |