Muzlifah 2009.
Study characteristics | ||
Methods | RCT | |
Participants | 80 women Inclusion criteria: ASA I or II women scheduled for elective CS under spinal anaesthesia, normal singleton pregnancy; > 36 weeks' gestation; BMI 20‐38 kg/m²; height > 145 cm Exclusion criteria: contraindications for spinal anaesthesia and failed spinal necessitating conversion to GA Setting: Malaysia |
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Interventions |
Crystalloids: different preload volumes Group 1: low volume crystalloid 10 mL/kg of Ringer's lactate infusion preload Group 2: high volume crystalloid 20 mL/kg of Ringer's lactate infusion preload All women received standardised aspiration prophylaxis, standardised anaesthetic technique and dose, standardised fluid maintenance. Hypotension was managed with 6 mg boluses of ephedrine. |
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Outcomes | Maternal: hypotension; BP; ephedrine requirement; nausea; vomiting; oxygen saturation; respiratory rate | |
Notes | Hypotension was defined as a > 20% fall in MAP from baseline. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Coin toss |
Allocation concealment (selection bias) | Unclear risk | "Randomly allocated" – no further details reported |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Described as "single blinded" – no further details reported |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | As above |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No losses to follow‐up reported |
Selective reporting (reporting bias) | High risk | No neonatal outcomes were reported |
Other bias | Low risk | Similar baseline characteristics |