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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Muzlifah 2009.

Study characteristics
Methods RCT
Participants 80 women
Inclusion criteria: ASA I or II women scheduled for elective CS under spinal anaesthesia, normal singleton pregnancy; > 36 weeks' gestation; BMI 20‐38 kg/m²; height > 145 cm
Exclusion criteria: contraindications for spinal anaesthesia and failed spinal necessitating conversion to GA
Setting: Malaysia
Interventions Crystalloids: different preload volumes
Group 1: low volume crystalloid 10 mL/kg of Ringer's lactate infusion preload
Group 2: high volume crystalloid 20 mL/kg of Ringer's lactate infusion preload
All women received standardised aspiration prophylaxis, standardised anaesthetic technique and dose, standardised fluid maintenance.
Hypotension was managed with 6 mg boluses of ephedrine.
Outcomes Maternal: hypotension; BP; ephedrine requirement; nausea; vomiting; oxygen saturation; respiratory rate
Notes Hypotension was defined as a > 20% fall in MAP from baseline.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Coin toss
Allocation concealment (selection bias) Unclear risk "Randomly allocated" – no further details reported
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Described as "single blinded" – no further details reported
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk As above
Incomplete outcome data (attrition bias)
All outcomes Low risk No losses to follow‐up reported
Selective reporting (reporting bias) High risk No neonatal outcomes were reported
Other bias Low risk Similar baseline characteristics