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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Oh 2014.

Study characteristics
Methods RCT
Participants 60 women
Inclusion criteria: ASA I, elective CS under spinal anaesthesia
Exclusion criteria: gestational age < 37 weeks, multiple gestation, fetal distress, pre‐eclampsia, cardiovascular disease, diabetes
Setting: South Korea
Interventions Comparison of crystalloid preload versus coload
Group 1: rapid infusion of 15 mL/kg Hartmann's preloading
Group 2: rapid infusion of 15 mL/kg Hartmann's just after intrathecal injection
All women had same monitoring, IV access, spinal anaesthetic technique and dose.
Hypotension treated with 5 mg IV ephedrine.
Outcomes Maternal: incidence of hypotension, nausea and vomiting
Neonatal: Apgar scores at 1 min and 5 min, umbilical cord gases
Notes Hypotension defined as a decrease of SBP > 20% from baseline
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random allocation (block randomisation, block size 4)
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias)
All outcomes Low risk Not blinded, but unlikely to have affected incidence of hypotension
Blinding of outcome assessment (detection bias)
All outcomes Low risk Not blinded, but unlikely to have affected incidence of hypotension
Incomplete outcome data (attrition bias)
All outcomes Low risk Group 1: 1 woman excluded due to surgical delay by other operation
Group 2: 1 woman excluded due to inadequate spinal anaesthesia
Selective reporting (reporting bias) Low risk Not apparent
Other bias Low risk Not apparent