Oh 2014.
Study characteristics | ||
Methods | RCT | |
Participants | 60 women Inclusion criteria: ASA I, elective CS under spinal anaesthesia Exclusion criteria: gestational age < 37 weeks, multiple gestation, fetal distress, pre‐eclampsia, cardiovascular disease, diabetes Setting: South Korea |
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Interventions |
Comparison of crystalloid preload versus coload Group 1: rapid infusion of 15 mL/kg Hartmann's preloading Group 2: rapid infusion of 15 mL/kg Hartmann's just after intrathecal injection All women had same monitoring, IV access, spinal anaesthetic technique and dose. Hypotension treated with 5 mg IV ephedrine. |
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Outcomes |
Maternal: incidence of hypotension, nausea and vomiting Neonatal: Apgar scores at 1 min and 5 min, umbilical cord gases |
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Notes | Hypotension defined as a decrease of SBP > 20% from baseline | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random allocation (block randomisation, block size 4) |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Not blinded, but unlikely to have affected incidence of hypotension |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Not blinded, but unlikely to have affected incidence of hypotension |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Group 1: 1 woman excluded due to surgical delay by other operation Group 2: 1 woman excluded due to inadequate spinal anaesthesia |
Selective reporting (reporting bias) | Low risk | Not apparent |
Other bias | Low risk | Not apparent |