Siddik 2000.
Study characteristics | ||
Methods | RCT | |
Participants | 40 women Inclusion criteria: non‐labouring ASA class I and II women scheduled for elective caesarean Exclusion criteria: obesity (> 115 kg), height > 152 cm, diabetes, pregnancy‐induced hypertension, chronic hypertension, heart disease, multiple gestation, breech presentation, age < 18 or > 40 and SBP < 100 mmHg Setting: Lebanon |
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Interventions |
Colloid v crystalloid preload Group 1: HES 10%, 500 mL Group 2: Ringer's lactate 1000 mL Preload was administered 10 min before spinal anaesthesia; women were placed in left supine wedged position. All women received a standardised spinal anaesthetic technique and dose. |
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Outcomes |
Maternal: hypotension; block height; ephedrine dose; heart rate; BP; nausea; vomiting Neonatal: Apgar scores; venous and arterial blood gases |
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Notes | Hypotension was defined as SBP < 80% baseline or < 100 mmHg | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation method not described |
Allocation concealment (selection bias) | Unclear risk | "Drawing shuffled sealed envelopes" |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Blinding: nurses placed a brown paper bag over the IV solution to conceal its identity from the anaesthetist |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | As above |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Losses to follow‐up not stated |
Selective reporting (reporting bias) | Unclear risk | Not apparent |
Other bias | Unclear risk | Not apparent |