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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Siddik 2000.

Study characteristics
Methods RCT
Participants 40 women
Inclusion criteria: non‐labouring ASA class I and II women scheduled for elective caesarean
Exclusion criteria: obesity (> 115 kg), height > 152 cm, diabetes, pregnancy‐induced hypertension, chronic hypertension, heart disease, multiple gestation, breech presentation, age < 18 or > 40 and SBP < 100 mmHg
Setting: Lebanon
Interventions Colloid v crystalloid preload
Group 1: HES 10%, 500 mL
Group 2: Ringer's lactate 1000 mL
Preload was administered 10 min before spinal anaesthesia; women were placed in left supine wedged position.
All women received a standardised spinal anaesthetic technique and dose.
Outcomes Maternal: hypotension; block height; ephedrine dose; heart rate; BP; nausea; vomiting
Neonatal: Apgar scores; venous and arterial blood gases
Notes Hypotension was defined as SBP < 80% baseline or < 100 mmHg
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomisation method not described
Allocation concealment (selection bias) Unclear risk "Drawing shuffled sealed envelopes"
Blinding of participants and personnel (performance bias)
All outcomes Low risk Blinding: nurses placed a brown paper bag over the IV solution to conceal its identity from the anaesthetist
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk As above
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Losses to follow‐up not stated
Selective reporting (reporting bias) Unclear risk Not apparent
Other bias Unclear risk Not apparent