Singh 2009.
Study characteristics | ||
Methods | Randomised, quasi‐experimental observational cohort study | |
Participants | 60 patients
Inclusion criteria: ASA I, elective LSCS Exclusion criteria: pregnancy‐induced high BP, high‐risk pregnancy, fetal distress, moderate to severe anaemia, patient refusal, infection at site of injection, bleeding diathesis, severe hypovolaemia, elevated intracranial pressure, spine deformity and patients with major systemic illness Setting: India |
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Interventions |
Crystalloid versus colloid preload Group 1: 20 mL/kg Ringer's lactate preloading over 20 min just prior to SAB Group 2: 10 mL/kg HES 130/0.4 (up to a max 500 mL) preloading over 20 min just prior to SAB All women received standardised premedication, positioning, monitoring, IV cannulation/urinary catheter, SAB and technique, oxygen delivery, intra‐operative fluids, oxytocin. Hypotension treated with IV bolus of crystalloid up to 200 mL, further hypotension treated with mephentermine 3 mg IV bolus every 1 min until SBP> 90 mmHg achieved. Bradycardia treated with atropine 300 μg aliquots. |
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Outcomes |
Maternal: haemodynamics/observations, urine output, duration of surgery, uterine incision‐delivery time, SAB complications, "undesirable effects" from HES including "anaphylactoid" reactions, pruritis, bleeding Neonatal: Apgar scores at 1 min and 5 min |
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Notes | Hypotension was defined as a fall in SAP > 30% of baseline or SAP < 90 mmHg | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not reported |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not reported |
Selective reporting (reporting bias) | Unclear risk | Not reported |
Other bias | Unclear risk | Not reported |