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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Singh 2009.

Study characteristics
Methods Randomised, quasi‐experimental observational cohort study
Participants 60 patients
Inclusion criteria: ASA I, elective LSCS
Exclusion criteria: pregnancy‐induced high BP, high‐risk pregnancy, fetal distress, moderate to severe anaemia, patient refusal, infection at site of injection, bleeding diathesis, severe hypovolaemia, elevated intracranial pressure, spine deformity and patients with major systemic illness
Setting: India
Interventions Crystalloid versus colloid preload
Group 1: 20 mL/kg Ringer's lactate preloading over 20 min just prior to SAB
Group 2: 10 mL/kg HES 130/0.4 (up to a max 500 mL) preloading over 20 min just prior to SAB
All women received standardised premedication, positioning, monitoring, IV cannulation/urinary catheter, SAB and technique, oxygen delivery, intra‐operative fluids, oxytocin.
Hypotension treated with IV bolus of crystalloid up to 200 mL, further hypotension treated with mephentermine 3 mg IV bolus every 1 min until SBP> 90 mmHg achieved. Bradycardia treated with atropine 300 μg aliquots.
Outcomes Maternal: haemodynamics/observations, urine output, duration of surgery, uterine incision‐delivery time, SAB complications, "undesirable effects" from HES including "anaphylactoid" reactions, pruritis, bleeding
Neonatal: Apgar scores at 1 min and 5 min
Notes Hypotension was defined as a fall in SAP > 30% of baseline or SAP < 90 mmHg
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not reported
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not reported
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Not reported
Selective reporting (reporting bias) Unclear risk Not reported
Other bias Unclear risk Not reported