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. 2020 Jul 1;2020(7):CD002251. doi: 10.1002/14651858.CD002251.pub4

Tercanli 2005.

Study characteristics
Methods RCT
Participants 22 women
Inclusion criteria: healthy women with uncomplicated singleton pregnancies at 36‐40 weeks' gestation, not in labour, undergoing elective caesarean under spinal anaesthesia
Interventions Crystalloid: high versus low volume preload
Group 1: 15 mL/kg Ringer's lactate
Group 2: 150 mL Ringer's lactate
All women received a standardised spinal anaesthetic technique and dose.
Outcomes Maternal: hypotension; ephedrine dose
Neonatal: pulsatility indices; pH (mean and SD); Apgar score at 1 min, 5 min, and 10 min (mean and SD); NACS
Notes Hypotension was defined as decrease in SBP of more than 20% from baseline.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method not described
Allocation concealment (selection bias) Low risk Adequate: drawing of sealed consecutive opaque sealed envelopes a day before surgery
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Blinding not stated
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Blinding not stated
Incomplete outcome data (attrition bias)
All outcomes Low risk Losses to follow‐up: not stated but losses unlikely
Selective reporting (reporting bias) Low risk Not apparent
Other bias Low risk Not apparent