Tercanli 2005.
Study characteristics | ||
Methods | RCT | |
Participants | 22 women Inclusion criteria: healthy women with uncomplicated singleton pregnancies at 36‐40 weeks' gestation, not in labour, undergoing elective caesarean under spinal anaesthesia |
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Interventions |
Crystalloid: high versus low volume preload Group 1: 15 mL/kg Ringer's lactate Group 2: 150 mL Ringer's lactate All women received a standardised spinal anaesthetic technique and dose. |
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Outcomes |
Maternal: hypotension; ephedrine dose Neonatal: pulsatility indices; pH (mean and SD); Apgar score at 1 min, 5 min, and 10 min (mean and SD); NACS |
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Notes | Hypotension was defined as decrease in SBP of more than 20% from baseline. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method not described |
Allocation concealment (selection bias) | Low risk | Adequate: drawing of sealed consecutive opaque sealed envelopes a day before surgery |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Blinding not stated |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Blinding not stated |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Losses to follow‐up: not stated but losses unlikely |
Selective reporting (reporting bias) | Low risk | Not apparent |
Other bias | Low risk | Not apparent |