3. Critical review form; studies with non‐randomised controls.

yes ‐ no

Did study population meet our criteria? or: is it possible to analyse patients that meet our criteria separately? Is the study adjusted for confounders? Were patients analysed in the groups to which they were assigned? Were the groups similar before treatment? Aside from the experimental intervention, were the groups treated equally? Are controls concurrent or retrospective? Were all patients accounted for at the end of follow up? How long was follow up? Were interventions defined adequately? How precise was the estimate of the treatment effect? ‐disease free survival ‐complications Were all clinically important outcomes considered? ‐disease free survival ‐complications