4. Critical review form; observational studies.

yes ‐ no

Did study population meet our criteria? or: is it possible to analyse patients that meet our criteria separately? Were all observed patients accounted for at the end of follow up? How long was follow up? Were interventions defined adequately? Is the study cohort defined temporally? Is the study cohort defined geographically? Percentage of defined patient population who are included in the study? Were all clinically important outcomes considered? ‐disease free survival ‐complications