Table 3.

Hazard to die in IM-treated patients with high- and low-risk ACA dependent on blast increase to 1–30% (Cox model).

	HR	Lower 95% CI	Upper 95% CI	P value	n
Peripheral blood (PB)
1% blasts in PB
Presence of high-risk ACAs	3.65	2.32	5.75	<0.001	224
Presence of low-risk ACAs	1.92	1.06	8.07	0.039
5% blasts in PB
Presence of high-risk ACAs		1.11	2.86	0.016	117
Presence of low-risk ACAs	1.77	0.68	4.66	0.244
10% blasts in PB
Presence of high-risk ACAs	1.39	0.87	2.21	0.167	107
Presence of low-risk ACAs	1.38	0.53	3.60	0.506
15% blasts in PB
Presence of high-risk ACAs	1.37	0.86	2.19	0.189	104
Presence of low-risk ACAs	1.32	0.51	3.42	0.568
20% blasts in PB
Presence of high-risk ACAs	0.84	0.50	1.40	0.502	79
Presence of low-risk ACAs	0.74	0.20	2.71	0.652
30% blasts in PB
Presence of high-risk ACAs	0.83	0.50	1.39	0.479	78
Presence of low-risk ACAs	0.76	0.20	2.89	0.689
Bone marrow (BM)
1% blasts in BM
Presence of high-risk ACAs	6.12	4.08	9.17	<0.001	1033
Presence of low-risk ACAs	2.71	0.99	7.44	0.053
5% blasts in BM
Presence of high-risk ACAs	5.46	3.58	8.33	<0.001	588
Presence of low-risk ACAs	3.21	1.16	8.85	0.024
10% blasts in BM
Presence of high-risk ACAs	2.21	1.37	3.56	0.001	134
Presence of low-risk ACAs	1.68	0.61	4.60	0.311
15% blasts in BM
Presence of high-risk ACAs	1.77	1.11	2.83	0.017	115
Presence of low-risk ACAs	1.66	0.63	4.37	0.309
20% blasts in BM
Presence of high-risk ACAs	1.24	0.74	2.06	0.416	87
Presence of low-risk ACAs	1.11	0.29	4.18	0.882
30% blasts in BM
Presence of high-risk ACAs	0.89	0.53	1.49	0.665	79
Presence of low-risk ACAs	0.81	0.21	3.07	0.760