Table 3.
Incidence of gain of chromosome 21 in hematological cancer.
| Subtype | Pediatric/Adult | Total cases (n) | Total +21 (n) | % of +21 | Reference |
|---|---|---|---|---|---|
| Myeloid disorders | |||||
| MPN | Adult | 938 | 36 | 3.8 | [144] and MDB |
| MDS | Adult | 3577 | 151 | 4.2 | [145] and MDB |
| AML | Pediatric | 3758 | 319 | 8.5 | [133] and MDB |
| Adult | 17769 | 695 | 3.9 | [134] and MDB | |
| AMKL | Pediatric | 372 | 126 | 33.9 | [121] and MDB |
| Adult | 203 | 15 | 7.4 | [121] and MDB | |
| Lymphoid disorders | |||||
| T-ALL | Pediatric | 1431 | 43 | 3.0 | [146] and MDB |
| Adult | 495 | 30 | 6.1 | MDB | |
| B-ALL | Pediatric | 3973 | 1086 | 27.3 | MDB |
| Adult | 1290 | 141 | 10.9 | MDB | |
| CLL | Adult | 1432 | 32 | 2.2 | MDB |
| FL | Adult | 906 | 87 | 9.6 | [140] and MDB |
| CTCL | Adult | 246 | 21 | 8.5 | [139, 140] and MDB |
MDB Mitelman database (updated on 15/10/2019, available at https://mitelmandatabase.isb-cgc.org), MPN myeloproliferative neoplasms, MDS myelodysplastic syndrome, AML acute myeloid leukemia, AMKL acute megakaryoblastic leukemia, T-ALL T-cell acute lymphoblastic leukemia, B-ALL B-cell acute lymphoblastic leukemia, CLL chronic lymphocytic leukemia, FL follicular lymphoma, CTCL cutaneous T-cell lymphoma.