Gurak 2005.

Methods	Parallel randomised trial Method of randomisation: simple randomisation Method of concealment: unclear Blinding: unclear Analysis: unclear
Participants	Location: Russia Setting: outpatient clinic Number of participants: 30 at randomisation and all completed the study (33% male, mean age 51 years) Treatment group: 15 Control group: 15 Stroke criteria: ischaemic, criteria unclear Time since stroke onset at randomisation: > 3 months after stroke Fatigue criteria: MFI‐20 Other entry criteria: unclear Comparability of groups: unclear
Interventions	Treatment intervention: enerion (a synthetic derivative of vitamin B1, 200 mg, twice per day, 30 days) plus standard rehabilitation Control intervention: standard rehabilitation Treatment duration: 30 days Delivered by: unclear
Outcomes	Time for fatigue assessment: baseline and at the end of 30‐day treatment Primary outcome: MFI‐20 (general fatigue, physical fatigue, low activity, low motivation and mental fatigue)
Notes	Only people with PSF (MFI‐20) were recruited Funding: no information available
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	High risk	Interventions used in the 2 groups were visibly different, so participants and medical staff would be aware of what was being used
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not enough information reported
Intention‐to‐treat	Low risk	No loss to follow‐up reported