Fig. 1. Mean volumes of total brain, total grey matter, total white matter, frontal lobe, temporal lobe, cerebellum and hippocampus were significantly reduced in individuals with 22q11.2DS.

There were no significant mean differences between groups for cerebral spinal fluid (CSF), parietal lobe, lateral ventricles, caudate nucleus or amygdala. CL Confidence Interval; P indicates statistical significance; I² indicates inconsistency.