Table 1.
Summary table of most promising recently published biomarkers and therapeutic targets
| SNC subtype | Biomarker | (Type) | Reference |
|---|---|---|---|
| ONB | Methylation classifier (developed for brain cancers) | Diagnostic |
Capper et al. (2018, Nature) Capper et al. (2018, Acta N) |
| Sinonasal melanoma | NRAS (G12 hot-spot mutation) and KIT | Therapeutic |
Chraybi et al. (2013) Turri-Zanoni et al. (2013) Wroblewska et al. (2019) |
| SNUC | IDH2 mutation | Diagnostic |
Jo et al. (2017); Dogan et al. (2017) Takahashi et al. (2019) |
| 24 gene panel for prediction of response to chemotherapy | Predictive | ||
| Sinonasal NUT midline carcinoma | Translocation of the gene encoding nuclear protein in testis (NUTM1) | Diagnostic | Stelow and Bishop (2017) |
| SNEC | Insulinoma-associated protein 1 (INSM1) | Diagnostic | Rooper, Bishop and Westra (2018) |
| Sinonasal adenocarcinoma | KRAS | Therapeutic |
Lopez et al. (2012) Szablewski et al. (2013) Garcia-Inclan et al. (2012) |
| SNSCC | EGFR | Therapeutic |
Udager et al. (2015) Li and Zhu et al. (2017) Quan et al. (2019) |
| TrkB | Prognostic | ||
| TIL | Prognostic/therapeutic |