| Thromboembolic risk is an important and emerging consideration for clinicians who prescribe Janus kinase (JAK) inhibitors. Older patients with rheumatoid arthritis are at increased thromboembolic risk because of age and comorbid conditions. |
| The warnings issued by the US FDA and the European Medicines Agency highlight this risk. |
| Infectious complications, such as herpes zoster, are known and essential considerations. |
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