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. 2020 Jul 28;10:12651. doi: 10.1038/s41598-020-69454-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multiple roles of cholesterol in glutamatergic synaptic transmission. The scheme shows processes affected by acute cholesterol depletion, thus summarizing components of synaptic transmission where endogenous cholesterol plays an active role. Disruption of action potential propagation is shown here as it is the most probable hypothesis explaining AMPAR eEPSC decrease after cholesterol depletion. Cholesterol depletion-induced synaptic delivery of AMPARs is not included in the scheme as this phenomenon is relatively weak (25% increase in synaptic AMPARs in our experimental conditions) compared to other phenomena in the scheme.