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. 2020 Jul 28;10:12652. doi: 10.1038/s41598-020-69380-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Apoptotic fractions of normal, PTEN-cancer and Wip1-cancer cells for the optimal protocols. Cancer cells receive irradiation dose IR_cancer (as given); normal cells receive threefold lower irradiation dose and have 10 or threefold lower inhibitor uptake (as given) than cancer cells. The same protocols as in Fig. 7 are considered but with the minimized inhibitor dose under the condition that the apoptotic fraction of normal cells remains below 10% and apoptotic fraction of cancer cells exceeds 95%.