Table 1.
The birth prevalence and percentage of specific CHD subtypes
| Specific subtypes | Number of studies | Event | Total | Birth prevalence, ‰ (95% confidence interval) | Percentage, % (95% confidence interval) |
|---|---|---|---|---|---|
| Twenty-one specific subtypes of CHD | |||||
| Atrial septal defect | 22 | 4967 | 3,750,686 | 1.314 (0.994–1.635) | 27.365 (26.716–28.013) |
| Patent ductus arteriosus | 21 | 3750 | 3,748,546 | 1.294 (1.037–1.550) | 20.660 (20.071–21.249) |
| Ventricular septal defect | 22 | 3,397 | 3,750,686 | 1.410 (1.176–1.645) | 18.715 (18.148–19.283) |
| Tetralogy of fallot | 19 | 661 | 3,466,248 | 0.210 (0.151–0.268) | 3.642 (3.369–3.914) |
| Atrioventricular septal defect | 14 | 488 | 3,394,004 | 0.146 (0.101–0.190) | 2.689 (2.453–2.924) |
| Tricuspid atresia or stenosis | 8 | 322 | 1,917,479 | 0.125 (0.036–0.213) | 1.774 (1.582–1.966) |
| Transposition of the great arteries | 14 | 268 | 2,289,051 | 0.133 (0.092–0.175) | 1.477 (1.301–1.652) |
| Pulmonary stenosis | 12 | 159 | 2,325,983 | 0.066 (0.036–0.096) | 0.876 (0.740–1.012) |
| Double outlet right ventricle | 8 | 122 | 2,122,417 | 0.059 (0.028–0.090) | 0.672 (0.553–0.791) |
| Endocardial cushion defect | 11 | 74 | 1,779,790 | 0.048 (0.025–0.071) | 0.408 (0.315–0.500) |
| Single ventricle | 12 | 64 | 1,858,797 | 0.034 (0.018–0.051) | 0.353 (0.266–0.439) |
| Truncus arteriosus | 9 | 47 | 1,533,718 | 0.038 (0.014–0.062) | 0.259 (0.185–0.333) |
| Hypoplastic left heart syndrome | 7 | 35 | 1,464,418 | 0.021 (0.007–0.035) | 0.193 (0.129–0.257) |
| Pulmonary atresia | 7 | 31 | 1,302,023 | 0.028 (0.005–0.052) | 0.171 (0.111–0.231) |
| Aortic stenosis | 5 | 24 | 1,214,226 | 0.016 (0.009–0.024) | 0.132 (0.079–0.185) |
| Coarctation of the aorta | 5 | 19 | 516,806 | 0.035 (0.019–0.051) | 0.105 (0.058–0.152) |
| Dextrocardia | 4 | 9 | 130,700 | 0.054 (0.014–0.094) | 0.050 (0.017–0.082) |
| Ebstein anomaly | 3 | 8 | 989,085 | 0.007 (0.002–0.012) | 0.044 (0.014–0.075) |
| Mitral insufficiency/regurgitation | 1 | 3 | 29,920 | 0.100 (0.000–0.214) | 0.017 (0.000–0.035) |
| Total anomalous pulmonary venous return | 1 | 2 | 20,928 | 0.096 (0.000–0.228) | 0.011 (0.000–0.026) |
| Interrupted aortic arch | 0 | 0 | 0 | – | – |
| Four lesions of CHD | |||||
| Severe lesions | 21 | 2134 | 3,748,546 | 0.762 (0.611–0.913) | 11.757 (11.288–12.226) |
| Mild lesions | 22 | 12,316 | 3,750,686 | 4.581 (3.755–5.407) | 67.853 (67.174–68.533) |
| Cyanotic lesions | 20 | 1719 | 3,509,203 | 0.608 (0.465–0.751) | 9.471 (9.045–9.897) |
| Acyanotic lesions | 22 | 12,731 | 3,750,686 | 4.781 (3.934–5.627) | 70.139 (69.474–70.805) |
| Total CHD | 617 | 201,934 | 76,961,354 | 2.502 (2.397–2.607) | – |
CHD congenital heart disease