Chen 2012.

Study characteristics
Methods	Study design: Historically controlled trial Study grouping: Methods: Participants were not on lipid medications within 2 months of the trial; therefore, no washout required. 3 months before‐and‐after study
Participants	Baseline Characteristics 2 mg n: 30 Age (years): 60.5 Males (n): 14 Females (n): 16 BMI: 23.8 Total cholesterol: 5.54 mmol/L(214 mg/dL) LDL cholesterol: 3.60 mmol/L(139 mg/dL) HDL cholesterol: 1.12 mmol/L(43 mg/dL) Triglycerides: 1.94 mmol/L(172 mg/dL) Included criteria: participants have primary hypertension, men and women aged 18 to 85 years. Excluded criteria: people who were taking lipid‐lowering drugs, nonsteroidal anti‐inflammatory drugs, anticoagulants, angiotensin receptor antagonists; also with liver and kidney and other organ dysfunction; other cardiovascular diseases; having infectious diseases; acute and chronic inflammatory disease, connective tissue disease, cancer, diabetes, thyroid disease; pregnant and lactating women Baseline Group Characteristics: There was no significant difference between the BMI and smoking status between groups
Interventions	Intervention Characteristics 2 mg
Outcomes	Total cholesterol Outcome type: Continuous LDL cholesterol Outcome type: Continuous HDL cholesterol Outcome type: Continuous Triglycerides Outcome type: Continuous
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Judgement Comment: Controlled before‐and‐after design
Allocation concealment (selection bias)	High risk	Judgement Comment: Controlled before‐and‐after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Judgement Comment: Lipid parameter measurements unlikely to be influenced by lack of blinding
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Judgement Comment: Lipid parameters were measured in a remote laboratory.
Selective reporting (reporting bias)	Low risk	Judgement Comment: LDL‐cholesterol outcome was reported.
Other bias	Unclear risk	Judgement Comment: source of funding not reported
Incomplete outcome data (attrition bias) Total cholesterol	Low risk	All participants were included in the efficacy analysis.
Incomplete outcome data (attrition bias) LDL cholesterol)	Low risk	All participants were included in the efficacy analysis.
Incomplete outcome data (attrition bias) HDL cholesterol	Low risk	All participants were included in the efficacy analysis.
Incomplete outcome data (attrition bias) Triglycerides	Low risk	All participants were included in the efficacy analysis.
Blinding of outcome assessment (detection bias)WDAEs	High risk	No comparison possible
Selective reporting (reporting bias) for WDAEs	High risk	No WDAE outcome reported